(A39.1+) Waterhouse-friderichsen syndrome

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90 819 in individuals diagnosis waterhouse-friderichsen syndrome confirmed

4 763 deaths with diagnosis waterhouse-friderichsen syndrome

5% mortality rate associated with the disease waterhouse-friderichsen syndrome

Etiology Pathogenesis Clinical Pattern Diagnostics Treatment Prevention

Diagnosis waterhouse-friderichsen syndrome is diagnosed Men are 12.65% more likely than Women

51 155

Men receive the diagnosis waterhouse-friderichsen syndrome

2 659 (5.2 %)

Died from this diagnosis.

100

39 664

Women receive the diagnosis waterhouse-friderichsen syndrome

2 104 (5.3 %)

Died from this diagnosis.

Risk Group for the Disease waterhouse-friderichsen syndrome - Men and Women aged 0-5

In Men diagnosis is most often set at age 0-74, 80-89

Less common in men the disease occurs at Age 75-79, 90-95+Less common in women the disease occurs at Age 95+

In Women diagnosis is most often set at age 0-94

Disease Features waterhouse-friderichsen syndrome

Absence or low individual and public risk

Waterhouse-friderichsen syndrome - what does this mean

Waterhouse-friderichsen syndrome is a rare and life-threatening condition caused by a bacterial infection, usually meningococcemia, which causes bleeding into the adrenal glands. this leads to a sudden and severe drop in blood pressure and shock, and can be fatal if not treated immediately.

What happens during the disease - waterhouse-friderichsen syndrome

Waterhouse-friderichsen syndrome is a life-threatening condition caused by the rapid and overwhelming infection of the body by the bacteria known as neisseria meningitidis. this bacteria is spread through contact with respiratory secretions and results in septic shock and disseminated intravascular coagulation (dic). the infection leads to a rapid decrease in blood pressure and the death of many of the body's cells, resulting in a severe skin rash, fever, abdominal pain, and other symptoms. in severe cases, the infection can cause the adrenal glands to fail, leading to a drop in blood pressure, shock, and death.

Clinical Pattern

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How does a doctor diagnose

Complete physical examination
Blood tests to check for infection
Urine tests to check for infection
CT scan of the chest and abdomen
Lumbar puncture to check for meningitis
Biopsy of the affected area
MRI of the brain
Ultrasound of the affected area
X-ray of the affected area

Treatment and Medical Assistance

Main goal of the treatment: To reduce mortality and minimize the severity of symptoms associated with Waterhouse-Friderichsen syndrome

Administer antibiotics to reduce bacterial infection
Provide supportive care to maintain adequate hydration, electrolyte balance, and oxygenation
Provide intravenous fluids to maintain blood pressure
Administer corticosteroids to reduce inflammation
Administer vasopressors to reduce hypotension
Provide blood transfusions to replace lost blood
Administer anticoagulants to prevent further clotting
Provide dialysis to remove toxins from the blood
Monitor vital signs and laboratory tests
Provide nutritional support to maintain energy levels

25 Days of Hospitalization Required

Average Time for Outpatient Care Not Established

Waterhouse-friderichsen syndrome - Prevention

Waterhouse-friderichsen syndrome can be prevented by avoiding infection with neisseria meningitidis, the bacteria that causes it. vaccination with the meningococcal vaccine is the most effective way to prevent infection. additionally, good hygiene practices, such as frequent handwashing and avoiding contact with people who are ill, can help reduce the risk of infection.

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