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(C92.4) Acute promyelocytic leukaemia [pml]
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2 243 317 in individuals diagnosis acute promyelocytic leukaemia [pml] confirmed
425 448 deaths with diagnosis acute promyelocytic leukaemia [pml]
19% mortality rate associated with the disease acute promyelocytic leukaemia [pml]
Diagnosis acute promyelocytic leukaemia [pml] is diagnosed Men are 6.82% more likely than Women
1 198 186
Men receive the diagnosis acute promyelocytic leukaemia [pml]
238 642 (19.9 %)Died from this diagnosis.
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1 045 131
Women receive the diagnosis acute promyelocytic leukaemia [pml]
186 806 (17.9 %)Died from this diagnosis.
Risk Group for the Disease acute promyelocytic leukaemia [pml] - Men aged 55-59 and Women aged 65-69
In Men diagnosis is most often set at age 0-95+
in in men, the disease manifests at any agein in women, the disease manifests at any age
In Women diagnosis is most often set at age 0-95+
Disease Features acute promyelocytic leukaemia [pml]
Absence or low individual and public risk
Acute promyelocytic leukaemia [pml] - what does this mean
Acute promyelocytic leukaemia (pml) is a type of cancer of the blood and bone marrow caused by a genetic mutation that results in an abnormal buildup of immature white blood cells in the body. this leads to a decrease in healthy white blood cells, red blood cells, and platelets, resulting in anemia, infections, and easy bruising and bleeding.
What happens during the disease - acute promyelocytic leukaemia [pml]
Acute promyelocytic leukaemia (apml) is a type of acute myeloid leukaemia caused by a chromosomal translocation involving the retinoic acid receptor alpha (rarα) gene. this translocation results in the fusion of the rarα gene with a variety of other genes, leading to uncontrolled proliferation of promyelocytes and impaired maturation of these cells, resulting in accumulation of immature promyelocytes in the bone marrow and peripheral blood. this accumulation of immature promyelocytes leads to anemia, thrombocytopenia, and leukocytosis.
Clinical Pattern
Acute promyelocytic leukaemia (PML) is a type of acute myeloid leukaemia characterised by the presence of abnormal promyelocytes in the bone marrow. It is typically associated with a rapid onset of symptoms including fatigue, pallor, fever, and easy bruising or bleeding. Other symptoms may include bone pain, an enlarged spleen, and a tendency to develop infections. Diagnosis is made through a combination of blood tests, bone marrow biopsy, and imaging studies. Treatment typically involves a combination of chemotherapy and targeted medications.
How does a doctor diagnose
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Treatment and Medical Assistance
More details coming soon
24 Days of Hospitalization Required
Average Time for Outpatient Care Not Established
Acute promyelocytic leukaemia [pml] - Prevention
Acute promyelocytic leukaemia (pml) is best prevented through early detection and prompt treatment of any underlying conditions that may lead to it, such as certain types of blood disorders or genetic abnormalities. additionally, individuals should be aware of any family history of pml and seek medical attention if any symptoms arise.