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(C94.4) Acute panmyelosis with myelofibrosis
More details coming soon
120 090 in individuals diagnosis acute panmyelosis with myelofibrosis confirmed
16 667 deaths with diagnosis acute panmyelosis with myelofibrosis
14% mortality rate associated with the disease acute panmyelosis with myelofibrosis
Diagnosis acute panmyelosis with myelofibrosis is diagnosed Men are 17.58% more likely than Women
70 602
Men receive the diagnosis acute panmyelosis with myelofibrosis
8 490 (12.0 %)Died from this diagnosis.
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49 488
Women receive the diagnosis acute panmyelosis with myelofibrosis
8 177 (16.5 %)Died from this diagnosis.
Risk Group for the Disease acute panmyelosis with myelofibrosis - Men aged 60-64 and Women aged 70-74
In Men diagnosis is most often set at age 0-14, 20-95+
Less common in men the disease occurs at Age 15-19Less common in women the disease occurs at Age 5-9, 15-19, 35-39, 95+
In Women diagnosis is most often set at age 0-5, 10-14, 20-34, 40-94
Disease Features acute panmyelosis with myelofibrosis
Absence or low individual and public risk
Acute panmyelosis with myelofibrosis - what does this mean
Acute panmyelosis with myelofibrosis is a rare disorder characterized by an abnormal proliferation of bone marrow cells, accompanied by an accumulation of fibrous tissue in the bone marrow, resulting in anemia, enlarged spleen, and other symptoms.
What happens during the disease - acute panmyelosis with myelofibrosis
Acute panmyelosis with myelofibrosis is a rare bone marrow disorder characterized by an abnormal proliferation of bone marrow cells, leading to an abnormal increase in the number of immature myeloid cells, accompanied by an increase in fibrotic tissue in the bone marrow. this results in bone marrow failure, anemia, thrombocytopenia, and leukopenia. the exact cause of the disorder is not known, but it is believed to be related to a genetic mutation or a viral infection.
Clinical Pattern
More details coming soon
How does a doctor diagnose
- Complete Blood Count (CBC)
- Bone Marrow Biopsy and Aspirate
- Cytogenetic Analysis
- Flow Cytometry
- Immunophenotyping
- Molecular Testing
- Liver Function Tests
- Imaging Studies (X-ray, CT, MRI, etc.)
- Lumbar Puncture
Treatment and Medical Assistance
Main Goal of Treatment: Reduce symptoms, slow disease progression, and improve quality of life.
- Medication therapy with hydroxyurea or anagrelide to reduce platelet counts
- Medication therapy with prednisone or other corticosteroids to reduce inflammation
- Medication therapy with ruxolitinib to reduce symptoms and improve quality of life
- Transfusions to replace red blood cells and platelets
- Bone marrow transplant to replace defective bone marrow cells
- Surgery to remove the spleen and reduce platelet counts
- Radiation therapy to reduce symptoms and slow disease progression
- Physical therapy to maintain strength and mobility
- Nutritional therapy to maintain a healthy diet
- Psychological counseling to manage stress, anxiety, and depression
14 Days of Hospitalization Required
Average Time for Outpatient Care Not Established
Acute panmyelosis with myelofibrosis - Prevention
The best way to prevent acute panmyelosis with myelofibrosis is to practice good hygiene and to avoid contact with people who are already infected. it is also important to get regular check-ups and to be aware of the signs and symptoms of the disease. additionally, it is important to maintain a healthy lifestyle by eating a balanced diet, exercising regularly, and avoiding smoking and excessive alcohol consumption.