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(D57.2) Double heterozygous sickling disorders
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65 661 in individuals diagnosis double heterozygous sickling disorders confirmed
2 472 deaths with diagnosis double heterozygous sickling disorders
4% mortality rate associated with the disease double heterozygous sickling disorders
Diagnosis double heterozygous sickling disorders is diagnosed Men are 15.12% more likely than Women
37 794
Men receive the diagnosis double heterozygous sickling disorders
804 (2.1 %)Died from this diagnosis.
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27 867
Women receive the diagnosis double heterozygous sickling disorders
1 668 (6.0 %)Died from this diagnosis.
Risk Group for the Disease double heterozygous sickling disorders - Men and Women aged 10-14
In Men diagnosis is most often set at age 0-59, 65-89
Less common in men the disease occurs at Age 60-64, 90-95+Less common in women the disease occurs at Age 50-54, 90-95+
In Women diagnosis is most often set at age 0-49, 55-89
Disease Features double heterozygous sickling disorders
Absence or low individual and public risk
Double heterozygous sickling disorders - what does this mean
Double heterozygous sickling disorders occur when a person has two copies of a mutated gene that causes sickle cell disease. this mutation causes the red blood cells to become sickle-shaped and unable to carry oxygen efficiently, resulting in symptoms such as anemia, fatigue, pain, and organ damage.
What happens during the disease - double heterozygous sickling disorders
Double heterozygous sickling disorders is a genetic disorder caused by a mutation in the hemoglobin gene. this mutation causes the red blood cells to become sickled and unable to effectively carry oxygen throughout the body. this leads to anemia, fatigue, organ damage, and other complications. it is inherited in an autosomal recessive pattern, meaning that both parents must carry the mutated gene in order for the child to be affected. treatment typically involves blood transfusions, medications, and lifestyle modifications.
Clinical Pattern
More details coming soon
How does a doctor diagnose
- Complete Blood Count (CBC)
- Hemoglobin Electrophoresis
- Hemoglobin Fractionation
- Red Blood Cell Indices
- Reticulocyte Count
- Osmotic Fragility Test
- Sickling Test
- Genetic Testing
Treatment and Medical Assistance
Main goal of the treatment: To reduce the severity of symptoms and improve the quality of life for those with double heterozygous sickling disorders.
- Identifying and managing risk factors such as infection, dehydration, and anemia.
- Providing preventive care including vaccinations and regular check-ups.
- Prescribing medications to reduce pain and prevent complications.
- Providing oxygen therapy to reduce the risk of complications.
- Performing regular blood transfusions to reduce the risk of anemia.
- Performing regular physical therapy to maintain muscle strength and flexibility.
- Providing psychological support to help manage stress and anxiety.
- Educating patients and their families about the condition and how to manage it.
11 Days of Hospitalization Required
Average Time for Outpatient Care Not Established
Double heterozygous sickling disorders - Prevention
The best way to prevent double heterozygous sickling disorders is to ensure that both parents are tested for the sickle cell trait before conception. if both parents are carriers, they should seek genetic counseling to discuss the risks of having a child with the disorder. additionally, regular prenatal care can help to identify any potential issues early on, allowing for early treatment if necessary.