DocSym
β
Searchsearch
Search
(D64.3) Other sideroblastic anaemias
More details coming soon
4 889 367 in individuals diagnosis other sideroblastic anaemias confirmed
90 104 deaths with diagnosis other sideroblastic anaemias
2% mortality rate associated with the disease other sideroblastic anaemias
Diagnosis other sideroblastic anaemias is diagnosed Women are 6.31% more likely than Men
2 290 469
Men receive the diagnosis other sideroblastic anaemias
40 996 (1.8 %)Died from this diagnosis.
100
95
90
85
80
75
70
65
60
55
50
45
40
35
30
25
20
15
10
5
0
2 598 898
Women receive the diagnosis other sideroblastic anaemias
49 108 (1.9 %)Died from this diagnosis.
Risk Group for the Disease other sideroblastic anaemias - Men aged 75-79 and Women aged 80-84
In Men diagnosis is most often set at age 0-95+
in in men, the disease manifests at any agein in women, the disease manifests at any age
In Women diagnosis is most often set at age 0-95+
Disease Features other sideroblastic anaemias
Absence or low individual and public risk
Other sideroblastic anaemias - what does this mean
Other sideroblastic anaemias are a group of anaemias caused by an abnormality in the production of red blood cells resulting from a defect in the metabolism of iron. this defect causes the body to produce red blood cells with an abnormal amount of iron, which cannot carry oxygen efficiently, leading to anaemia.
What happens during the disease - other sideroblastic anaemias
Other sideroblastic anaemias are a group of inherited or acquired anaemias characterised by the presence of ringed sideroblasts in the bone marrow. these anaemias are caused by a defect in the haem biosynthesis pathway resulting in impaired production of haemoglobin and hence anaemia. this is caused by a defect in the enzymes involved in the haem biosynthesis pathway, such as alas2, leading to an accumulation of iron in the mitochondria of the red blood cells. this leads to the formation of ringed sideroblasts, which are immature red blood cells containing iron-containing granules.
Clinical Pattern
More details coming soon
How does a doctor diagnose
- Complete Blood Count (CBC)
- Peripheral Blood Smear
- Bone Marrow Biopsy and Aspirate
- Erythrocyte Sedimentation Rate (ESR)
- Serum Iron, Total Iron Binding Capacity, and Ferritin
- Hemoglobin Electrophoresis
- Molecular Testing for Genetic Mutations
- Liver Function Tests
- Thyroid Function Tests
Treatment and Medical Assistance
Main goal: Treat the underlying cause of the other sideroblastic anaemias.
- Assess for any underlying causes such as medications, infection, or malignancy.
- Evaluate for any nutritional deficiencies and provide appropriate supplementation.
- Administer drugs that inhibit the production of erythropoietin, such as phenylbutazone.
- Administer medications to increase the production of red blood cells, such as vitamin B6.
- Administer drugs to reduce the production of red blood cells, such as hydroxyurea.
- Perform a bone marrow transplant.
- Provide supportive care, such as transfusions and iron supplementation.
13 Days of Hospitalization Required
Average Time for Outpatient Care Not Established
Other sideroblastic anaemias - Prevention
Other sideroblastic anaemias can be prevented by avoiding alcohol consumption, maintaining a healthy diet rich in iron and vitamin b12, and avoiding exposure to toxins such as lead. additionally, regular medical check-ups can help to identify any underlying causes and provide early intervention.