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(E27.1) Primary adrenocortical insufficiency
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509 683 in individuals diagnosis primary adrenocortical insufficiency confirmed
8 862 deaths with diagnosis primary adrenocortical insufficiency
2% mortality rate associated with the disease primary adrenocortical insufficiency
Diagnosis primary adrenocortical insufficiency is diagnosed Women are 33.69% more likely than Men
168 997
Men receive the diagnosis primary adrenocortical insufficiency
3 665 (2.2 %)Died from this diagnosis.
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340 686
Women receive the diagnosis primary adrenocortical insufficiency
5 197 (1.5 %)Died from this diagnosis.
Risk Group for the Disease primary adrenocortical insufficiency - Men aged 60-64 and Women aged 55-59
In Men diagnosis is most often set at age 0-94
Less common in men the disease occurs at Age 95+in in women, the disease manifests at any age
In Women diagnosis is most often set at age 0-95+
Disease Features primary adrenocortical insufficiency
Absence or low individual and public risk
Primary adrenocortical insufficiency - what does this mean
Primary adrenocortical insufficiency is caused by a deficiency of cortisol production from the adrenal glands due to a destruction of the cells in the adrenal cortex, usually by an autoimmune process. this can lead to a disruption of the body's normal hormone balance and cause a wide range of symptoms.
What happens during the disease - primary adrenocortical insufficiency
Primary adrenocortical insufficiency is caused by an impaired ability of the adrenal glands to produce cortisol and other hormones. this is usually due to an autoimmune disorder, genetic defect, or infection that damages the adrenal cortex, leading to decreased production of cortisol and other hormones, resulting in a wide range of symptoms including fatigue, nausea, vomiting, and weight loss.
Clinical Pattern
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How does a doctor diagnose
- Obtain a detailed medical history and physical examination
- Measurement of serum electrolytes, glucose, and creatinine levels
- Measurement of cortisol levels in serum, saliva, or urine
- Measurement of adrenocorticotropic hormone (ACTH) levels in serum
- Measurement of aldosterone levels in serum
- Imaging studies such as computed tomography (CT) scan or magnetic resonance imaging (MRI) of the adrenal glands
- Genetic testing for adrenal enzyme deficiencies
- Adrenal biopsy
Treatment and Medical Assistance
Main goal of the treatment: To replace the missing cortisol and aldosterone hormones
- Prescribing glucocorticoid and mineralocorticoid hormones
- Monitoring electrolyte levels
- Providing dietary advice to maintain healthy levels of sodium and potassium
- Providing lifestyle advice to reduce stress and improve overall health
- Monitoring blood pressure
- Prescribing other medications to treat symptoms such as fatigue, nausea, and vomiting
- Monitoring for signs of infection
- Providing psychological support to help manage stress and anxiety
- Providing education about the disease and treatment options
11 Days of Hospitalization Required
Average Time for Outpatient Care Not Established
Primary adrenocortical insufficiency - Prevention
Primary adrenocortical insufficiency is a rare disorder, so there is no specific method of prevention. however, it is important to maintain a healthy lifestyle, including regular exercise and a balanced diet, to help reduce the risk of developing the condition. additionally, individuals should consult their doctor if they experience any of the symptoms associated with the disorder, such as fatigue, weight loss, or muscle weakness.