(L12.1) Cicatricial pemphigoid

More details coming soon

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231 237 in individuals diagnosis cicatricial pemphigoid confirmed
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8 706 deaths with diagnosis cicatricial pemphigoid
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4% mortality rate associated with the disease cicatricial pemphigoid

Diagnosis cicatricial pemphigoid is diagnosed Women are 18.79% more likely than Men

93 894

Men receive the diagnosis cicatricial pemphigoid

3 346 (3.6 %)

Died from this diagnosis.

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137 343

Women receive the diagnosis cicatricial pemphigoid

5 360 (3.9 %)

Died from this diagnosis.

Risk Group for the Disease cicatricial pemphigoid - Men and Women aged 80-84

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In Men diagnosis is most often set at age 0-14, 25-95+
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Less common in men the disease occurs at Age 15-24in in women, the disease manifests at any age
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In Women diagnosis is most often set at age 0-95+

Disease Features cicatricial pemphigoid

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Absence or low individual and public risk
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Cicatricial pemphigoid - what does this mean

Cicatricial pemphigoid is an autoimmune disorder in which antibodies attack the proteins of the skin and mucous membranes, leading to inflammation and scarring of the affected areas. this can result in blisters, erosions, and scarring of the skin and mucous membranes.

What happens during the disease - cicatricial pemphigoid

Cicatricial pemphigoid is an autoimmune disorder caused by the production of autoantibodies that target proteins in the basement membrane of the skin and mucous membranes. the autoantibodies cause an inflammatory response that leads to the destruction of the basement membrane and the formation of scar tissue. this can lead to the formation of blisters, erosions, and ulcers in the affected areas.

Clinical Pattern

More details coming soon

How does a doctor diagnose

  • Physical examination of the affected area
  • Skin biopsy
  • Direct immunofluorescence test
  • Indirect immunofluorescence test
  • Immunoblotting
  • Serological tests
  • Oral mucosa biopsy
Additional measures:
  • CT Scan
  • MRI Scan

Treatment and Medical Assistance

Main goal of the treatment: To reduce inflammation and prevent blistering.
  • Prescribe oral corticosteroids, such as prednisone, to reduce inflammation.
  • Prescribe topical corticosteroids, such as clobetasol, to reduce inflammation.
  • Prescribe topical immunosuppressants, such as tacrolimus, to reduce inflammation.
  • Prescribe oral immunosuppressants, such as cyclosporine, to reduce inflammation.
  • Prescribe biologic therapies, such as rituximab, to reduce inflammation.
  • Prescribe topical antibiotics, such as mupirocin, to reduce infection.
  • Prescribe topical antiseptics, such as povidone-iodine, to reduce infection.
  • Prescribe topical anti-itch medications, such as hydrocortisone, to reduce itching.
  • Prescribe oral anti-itch medications, such as diphenhydramine, to reduce itching.
  • Prescribe topical moisturizers, such as petroleum jelly, to reduce dryness.
  • Prescribe oral antihistamines, such as cetirizine, to reduce itching.
  • Prescribe topical anti-inflammatory medications, such as diclofenac, to reduce inflammation.
  • Prescribe ultraviolet light therapy, such as PUVA, to reduce inflammation.
  • Prescribe topical retinoids, such as tretinoin, to reduce inflammation.
  • Prescribe oral retinoids, such as isotretinoin, to reduce inflammation.
  • Prescribe topical calcineurin inhibitors, such as pimecrolimus, to reduce inflammation.
  • Prescribe topical photodynamic therapy, such as aminolevulinic acid, to reduce inflammation.
  • Prescribe topical antioxidants, such as vitamin E, to reduce inflammation.
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22 Days of Hospitalization Required
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Average Time for Outpatient Care Not Established

Cicatricial pemphigoid - Prevention

Cicatricial pemphigoid can be prevented by avoiding exposure to certain medications, such as non-steroidal anti-inflammatory drugs (nsaids), certain antibiotics, and anticonvulsants. additionally, it is important to practice good skin hygiene, including avoiding harsh soaps and detergents, and using moisturizers to keep the skin hydrated. sun protection is also important, as the sun can trigger the condition in some people.

Specified forms of the disease

(K45.0) Other specified abdominal hernia with obstruction, without gangrene
(K45.1) Other specified abdominal hernia with gangrene
(K45.8) Other specified abdominal hernia without obstruction or gangrene