(L12.1) Cicatricial pemphigoid

Cicatricial pemphigoid is an autoimmune disorder in which antibodies attack the proteins of the skin and mucous membranes, leading to inflammation and scarring of the affected areas. this can result in blisters, erosions, and scarring of the skin and mucous membranes.

Cicatricial pemphigoid is an autoimmune disorder caused by the production of autoantibodies that target proteins in the basement membrane of the skin and mucous membranes. the autoantibodies cause an inflammatory response that leads to the destruction of the basement membrane and the formation of scar tissue. this can lead to the formation of blisters, erosions, and ulcers in the affected areas.

More details coming soon

• Physical examination of the affected area
• Skin biopsy
• Direct immunofluorescence test
• Indirect immunofluorescence test
• Immunoblotting
• Serological tests
• Oral mucosa biopsy

Additional measures:

• CT Scan
• MRI Scan

Main goal of the treatment: To reduce inflammation and prevent blistering.

• Prescribe oral corticosteroids, such as prednisone, to reduce inflammation.
• Prescribe topical corticosteroids, such as clobetasol, to reduce inflammation.
• Prescribe topical immunosuppressants, such as tacrolimus, to reduce inflammation.
• Prescribe oral immunosuppressants, such as cyclosporine, to reduce inflammation.
• Prescribe biologic therapies, such as rituximab, to reduce inflammation.
• Prescribe topical antibiotics, such as mupirocin, to reduce infection.
• Prescribe topical antiseptics, such as povidone-iodine, to reduce infection.
• Prescribe topical anti-itch medications, such as hydrocortisone, to reduce itching.
• Prescribe oral anti-itch medications, such as diphenhydramine, to reduce itching.
• Prescribe topical moisturizers, such as petroleum jelly, to reduce dryness.
• Prescribe oral antihistamines, such as cetirizine, to reduce itching.
• Prescribe topical anti-inflammatory medications, such as diclofenac, to reduce inflammation.
• Prescribe ultraviolet light therapy, such as PUVA, to reduce inflammation.
• Prescribe topical retinoids, such as tretinoin, to reduce inflammation.
• Prescribe oral retinoids, such as isotretinoin, to reduce inflammation.
• Prescribe topical calcineurin inhibitors, such as pimecrolimus, to reduce inflammation.
• Prescribe topical photodynamic therapy, such as aminolevulinic acid, to reduce inflammation.
• Prescribe topical antioxidants, such as vitamin E, to reduce inflammation.

Cicatricial pemphigoid can be prevented by avoiding exposure to certain medications, such as non-steroidal anti-inflammatory drugs (nsaids), certain antibiotics, and anticonvulsants. additionally, it is important to practice good skin hygiene, including avoiding harsh soaps and detergents, and using moisturizers to keep the skin hydrated. sun protection is also important, as the sun can trigger the condition in some people.