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(D57) Sickle-cell disorders
More details coming soon
65 661 in individuals diagnosis sickle-cell disorders confirmed
2 472 deaths with diagnosis sickle-cell disorders
4% mortality rate associated with the disease sickle-cell disorders
Diagnosis sickle-cell disorders is diagnosed Men are 15.12% more likely than Women
37 794
Men receive the diagnosis sickle-cell disorders
804 (2.1 %)Died from this diagnosis.
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27 867
Women receive the diagnosis sickle-cell disorders
1 668 (6.0 %)Died from this diagnosis.
Risk Group for the Disease sickle-cell disorders - Men and Women aged 10-14
In Men diagnosis is most often set at age 0-59, 65-89
Less common in men the disease occurs at Age 60-64, 90-95+Less common in women the disease occurs at Age 50-54, 90-95+
In Women diagnosis is most often set at age 0-49, 55-89
Disease Features sickle-cell disorders
Absence or low individual and public risk
Sickle-cell disorders - what does this mean
Sickle-cell disorders are a group of inherited red blood cell disorders caused by a mutation in the hemoglobin gene. this mutation causes the red blood cells to become rigid and sickle-shaped, which can block small blood vessels and cause anemia, organ damage, pain, and other serious complications.
What happens during the disease - sickle-cell disorders
Sickle-cell disorders are caused by a mutation in the hemoglobin gene that results in the production of abnormal hemoglobin molecules. these abnormal hemoglobin molecules cause red blood cells to become rigid and sickle-shaped, which can block small blood vessels, leading to decreased oxygen delivery to tissues throughout the body. this can cause episodes of severe pain, organ damage, anemia, and other complications.
Clinical Pattern
More details coming soon
How does a doctor diagnose
- Complete Blood Count (CBC) Test
- Hemoglobin Electrophoresis
- Hemoglobin Solubility Test
- Sickle Cell Antibody Test
- High Performance Liquid Chromatography (HPLC)
- DNA Analysis
- Bone Marrow Biopsy
- Blood Smear Test
Treatment and Medical Assistance
Main goal of the treatment: To reduce pain and improve quality of life for people living with sickle-cell disorders.
- Hydration therapy
- Pain management
- Blood transfusions
- Antibiotics to prevent infections
- Folic acid supplements
- Exercise and physical therapy
- Vaccinations
- Stem cell transplantation
11 Days of Hospitalization Required
Average Time for Outpatient Care Not Established
Sickle-cell disorders - Prevention
Sickle-cell disorders can be prevented by avoiding exposure to environmental triggers such as extreme temperatures, dehydration, and stress. additionally, individuals should receive regular preventive care from a healthcare provider and take preventive measures such as drinking plenty of fluids, avoiding alcohol and smoking, and maintaining a healthy lifestyle. vaccinations may also be recommended to reduce the risk of infection.