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(M83.5) Other drug-induced osteomalacia in adults
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14 826 in individuals diagnosis other drug-induced osteomalacia in adults confirmed
372 deaths with diagnosis other drug-induced osteomalacia in adults
3% mortality rate associated with the disease other drug-induced osteomalacia in adults
Diagnosis other drug-induced osteomalacia in adults is diagnosed Women are 20.49% more likely than Men
5 894
Men receive the diagnosis other drug-induced osteomalacia in adults
0 (less than 0.1%)Died from this diagnosis.
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8 932
Women receive the diagnosis other drug-induced osteomalacia in adults
372 (4.2 %)Died from this diagnosis.
Risk Group for the Disease other drug-induced osteomalacia in adults - Men aged 40-44 and Women aged 55-59
In Men diagnosis is most often set at age 0-5, 15-19, 25-79, 85-89
Less common in men the disease occurs at Age 0-1, 5-14, 20-24, 80-84, 90-95+Less common in women the disease occurs at Age 0-9, 30-34, 95+
In Women diagnosis is most often set at age 10-29, 35-94
Disease Features other drug-induced osteomalacia in adults
Absence or low individual and public risk
Other drug-induced osteomalacia in adults - what does this mean
Other drug-induced osteomalacia in adults is caused by long-term use of certain medications, such as anticonvulsants, proton pump inhibitors, and antiretrovirals, which interfere with the body's ability to absorb or use vitamin d. this leads to a decrease in the amount of calcium and phosphate in the bones, resulting in weakened bones and an increased risk of fractures.
What happens during the disease - other drug-induced osteomalacia in adults
Other drug-induced osteomalacia in adults is caused by a decrease in the active form of vitamin d due to the use of certain medications, such as anticonvulsants, antifungals, and antiretrovirals. this decrease in vitamin d leads to a decrease in calcium absorption from the intestine, which results in a decrease in the mineralization of bone, leading to osteomalacia.
Clinical Pattern
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How does a doctor diagnose
- Detailed medical history review
- Physical examination
- Laboratory tests including serum calcium, phosphorus, alkaline phosphatase, and 25-hydroxyvitamin D levels
- Urinary calcium and phosphorus levels
- Bone biopsy
- X-rays of the affected bones
- CT scan of the affected bones
- MRI of the affected bones
Treatment and Medical Assistance
Main goal of the treatment: To restore normal vitamin D metabolism and improve bone mineralization
- Administer high doses of vitamin D to correct the deficiency
- Increase dietary intake of calcium and phosphorus
- Prescribe bisphosphonates to increase bone mineral density
- Monitor serum calcium and phosphorus levels
- Prescribe antiresorptive agents to reduce bone resorption
- Instruct patient to avoid drugs that interfere with vitamin D metabolism
- Encourage patient to engage in regular physical activity
- Monitor patient's response to therapy
23 Days of Hospitalization Required
Average Time for Outpatient Care Not Established
Other drug-induced osteomalacia in adults - Prevention
The best way to prevent other drug-induced osteomalacia in adults is to avoid the use of drugs that can cause this condition, such as anticonvulsants, antacids, and antiretrovirals. additionally, it is important to ensure that the dosage of any drugs being taken is appropriate and that any changes in medications are monitored closely. finally, regular exercise and adequate calcium and vitamin d intake can help to reduce the risk of osteomalacia.