(P57.0) Kernicterus due to isoimmunization

Kernicterus due to isoimmunization is a form of brain damage that occurs when a pregnant woman's immune system produces antibodies that attack the red blood cells of her fetus. this can cause the fetus to become jaundiced, resulting in the accumulation of high levels of bilirubin in the brain, leading to permanent brain damage.

Kernicterus due to isoimmunization is a rare form of brain damage resulting from an incompatibility between the mother's and baby's blood types. when the mother's body produces antibodies to the baby's red blood cells, these antibodies can cross the placenta and cause the baby's red blood cells to break down, resulting in a buildup of bilirubin in the baby's blood. when the bilirubin reaches a high level, it can cross the blood-brain barrier and cause damage to the baby's brain, leading to permanent neurological damage and the condition known as kernicterus.

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Main Goal: To reduce the neurological damage caused by Kernicterus due to isoimmunization.

• Perform exchanges transfusions to reduce bilirubin levels.
• Administer phototherapy to reduce the production of bilirubin.
• Administer intravenous immunoglobulin to reduce the production of antibodies.
• Monitor bilirubin levels to ensure that they are within safe ranges.
• Provide supportive care to reduce the risk of complications.
• Provide physical therapy to help improve motor skills.
• Provide speech therapy to help improve communication.
• Provide occupational therapy to help improve daily living activities.
• Provide psychological counseling to help with emotional issues.

Kernicterus due to isoimmunization can be prevented through antenatal screening and prophylactic treatment of rh-sensitized mothers with anti-d immunoglobulin, as well as early detection and treatment of newborns who are at risk.