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(Q93.0) Whole chromosome monosomy, meiotic nondisjunction
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17 019 in individuals diagnosis whole chromosome monosomy, meiotic nondisjunction confirmed
4 165 deaths with diagnosis whole chromosome monosomy, meiotic nondisjunction
25% mortality rate associated with the disease whole chromosome monosomy, meiotic nondisjunction
Diagnosis whole chromosome monosomy, meiotic nondisjunction is diagnosed Men are 7.64% more likely than Women
9 160
Men receive the diagnosis whole chromosome monosomy, meiotic nondisjunction
1 770 (19.3 %)Died from this diagnosis.
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7 859
Women receive the diagnosis whole chromosome monosomy, meiotic nondisjunction
2 395 (30.5 %)Died from this diagnosis.
Risk Group for the Disease whole chromosome monosomy, meiotic nondisjunction - Men and Women aged 0-5
In Men diagnosis is most often set at age 0-24
Less common in men the disease occurs at Age 25-95+Less common in women the disease occurs at Age 30-34, 40-95+
In Women diagnosis is most often set at age 0-29, 35-39
Disease Features whole chromosome monosomy, meiotic nondisjunction
Absence or low individual and public risk
Whole chromosome monosomy, meiotic nondisjunction - what does this mean
Whole chromosome monosomy, meiotic nondisjunction occurs when a gamete (sex cell) is formed with only one copy of a particular chromosome instead of the normal two copies, due to a failure of the chromosomes to separate properly during meiosis. this results in an embryo having one less chromosome than normal, leading to a variety of health problems.
What happens during the disease - whole chromosome monosomy, meiotic nondisjunction
Whole chromosome monosomy is a genetic disorder caused by meiotic nondisjunction, which is the failure of homologous chromosomes to separate during meiosis. this results in the production of gametes with an abnormal number of chromosomes, leading to aneuploidy, or an abnormal number of chromosomes in the cells of the organism. in the case of whole chromosome monosomy, this results in the absence of one of the chromosomes, leading to a wide range of physical and mental disabilities.
Clinical Pattern
More details coming soon
How does a doctor diagnose
- Complete physical examination
- Complete blood count
- Chromosome analysis
- Fluorescence in situ hybridization (FISH)
- Karyotyping
- Cytogenetic analysis
- Genetic testing
- Ultrasound imaging
Treatment and Medical Assistance
Main goal of the treatment: To correct the chromosomal abnormality.
- Genetic counselling
- Chromosomal analysis
- In vitro fertilization (IVF)
- Preimplantation genetic diagnosis (PGD)
- Chromosome replacement therapy (CRT)
- Gene therapy
- Gene editing
- Surrogacy
27 Days of Hospitalization Required
Average Time for Outpatient Care Not Established
Whole chromosome monosomy, meiotic nondisjunction - Prevention
Whole chromosome monosomy, meiotic nondisjunction can be prevented by reducing the risk factors that can lead to the condition, such as advanced maternal age, certain medications, and exposure to certain environmental toxins. genetic counseling may also be beneficial to those at risk for this condition.