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(T51.1) Toxic effect: methanol
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2 772 075 in individuals diagnosis toxic effect: methanol confirmed
Diagnosis toxic effect: methanol is diagnosed Men are 53.75% more likely than Women
2 130 980
Men receive the diagnosis toxic effect: methanol
0 (less than 0.1%)Died from this diagnosis.
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641 095
Women receive the diagnosis toxic effect: methanol
0 (less than 0.1%)Died from this diagnosis.
Risk Group for the Disease toxic effect: methanol - Men aged 50-54 and Women aged 15-19
In Men diagnosis is most often set at age 0-95+
in in men, the disease manifests at any agein in women, the disease manifests at any age
In Women diagnosis is most often set at age 0-95+
Disease Features toxic effect: methanol
Absence or low individual and public risk
Toxic effect: methanol - what does this mean
Methanol toxicity occurs when an individual is exposed to large amounts of methanol, either through ingestion, inhalation, or skin contact. the methanol is then metabolized by the liver, forming toxic metabolites which can cause severe damage to the central nervous system, eyes, and other organs. symptoms of methanol toxicity may include nausea, vomiting, confusion, visual disturbances, and respiratory depression.
What happens during the disease - toxic effect: methanol
Toxic effect of methanol is due to its metabolism by alcohol dehydrogenase in the liver to formaldehyde and formic acid, which are toxic metabolites. these metabolites cause metabolic acidosis, which leads to cell death and tissue damage. in addition, formic acid can cause blindness due to its accumulation in the retina.
Clinical Pattern
More details coming soon
How does a doctor diagnose
- Physical examination to assess symptoms
- Blood tests to measure methanol levels
- Urine tests to measure methanol levels
- Imaging tests such as MRI or CT scan to check for any damage to the brain or other organs
- Liver function tests to check for any damage to the liver
- Electrocardiogram (ECG) to check for any changes in the heart rhythm
- Lung function tests to check for any damage to the lungs
- Eye tests to check for any damage to the eyes
Treatment and Medical Assistance
Main Goal: Treating the toxic effects of methanol
- Administering fomepizole or ethanol to inhibit metabolism of methanol.
- Administering hemodialysis to remove methanol from the bloodstream.
- Administering bicarbonate to alkalinize the urine and increase methanol excretion.
- Monitoring and managing acid-base balance.
- Administering IV fluids to maintain hydration and urinary output.
- Providing supportive care such as oxygen and mechanical ventilation.
- Administering corticosteroids to reduce inflammation and edema.
- Providing nutritional support.
- Monitoring neurological status.
5 Days of Hospitalization Required
Average Time for Outpatient Care Not Established
Toxic effect: methanol - Prevention
Methanol toxicity can be prevented by avoiding ingestion of the substance, wearing protective gear when handling it, and disposing of it properly. additionally, individuals should ensure that any containers of methanol are labeled and stored safely away from food and drink.