Pain in the scrotum is a symptom of a medical condition. It may be felt as a sharp, burning, or aching sensation and may worsen with movement. It may be localized to one side of the scrotum or may be felt throughout the area. It can range from mild to severe and may be accompanied by swelling, redness, and tenderness. In some cases, it may be accompanied by a fever, nausea, or vomiting. Pain in the scrotum can be caused by a variety of conditions, including infection, trauma, or an underlying medical condition.