Intermittent claudication is a symptom of peripheral artery disease, which is characterized by cramping, pain, and fatigue in the muscles of the legs during physical activity. It occurs when the arteries become narrowed or blocked, reducing blood flow to the legs. Symptoms usually develop gradually and can range from mild to severe. Manifestations may include pain in the hips, thighs, calves, or feet, as well as numbness, tingling, or weakness in the legs. Pain is typically relieved with rest and worsens with activity.