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(D83.2) Common variable immunodeficiency with autoantibodies to b- or t-cells
More details coming soon
174 785 in individuals diagnosis common variable immunodeficiency with autoantibodies to b- or t-cells confirmed
3 186 deaths with diagnosis common variable immunodeficiency with autoantibodies to b- or t-cells
2% mortality rate associated with the disease common variable immunodeficiency with autoantibodies to b- or t-cells
Diagnosis common variable immunodeficiency with autoantibodies to b- or t-cells is diagnosed Men are 19.46% more likely than Women
104 402
Men receive the diagnosis common variable immunodeficiency with autoantibodies to b- or t-cells
1 828 (1.8 %)Died from this diagnosis.
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70 383
Women receive the diagnosis common variable immunodeficiency with autoantibodies to b- or t-cells
1 358 (1.9 %)Died from this diagnosis.
Risk Group for the Disease common variable immunodeficiency with autoantibodies to b- or t-cells - Men and Women aged 0-5
In Men diagnosis is most often set at age 0-64, 70-89
Less common in men the disease occurs at Age 65-69, 90-95+Less common in women the disease occurs at Age 80-89, 95+
In Women diagnosis is most often set at age 0-79, 90-94
Disease Features common variable immunodeficiency with autoantibodies to b- or t-cells
Absence or low individual and public risk
Common variable immunodeficiency with autoantibodies to b- or t-cells - what does this mean
Common variable immunodeficiency with autoantibodies to b- or t-cells is a rare disorder in which the body produces autoantibodies that attack and destroy its own b- or t-cells, resulting in a weakened immune system and an increased susceptibility to infections.
What happens during the disease - common variable immunodeficiency with autoantibodies to b- or t-cells
Common variable immunodeficiency with autoantibodies to b- or t-cells is caused by an impaired ability to produce antibodies, resulting in a decreased ability to fight off infections. this is due to a defective immune response, caused by a mutation in the genes responsible for producing b- and t-cells, or autoantibodies that attack b- and t-cells. this causes an imbalance in the immune system, leading to an increased susceptibility to infections and other health problems.
Clinical Pattern
More details coming soon
How does a doctor diagnose
- Complete blood count
- Lymphocyte phenotype analysis
- Immunoglobulin quantification
- Flow cytometry to identify B- and T-cell populations
- Antibody quantification and characterization
- Functional assessment of B- and T-cell responses
- Genetic analysis of the underlying cause
Treatment and Medical Assistance
Main Goal: To restore a normal immune system and reduce the production of autoantibodies
- Administering immunoglobulin replacement therapy
- Administering immunosuppressive drugs
- Administering intravenous immunoglobulin
- Administering bone marrow transplantation
- Administering plasma exchange
- Administering stem cell transplantation
- Administering monoclonal antibodies
- Administering biologic therapy
- Administering corticosteroids
- Administering anti-CD20 monoclonal antibody
- Administering recombinant human interleukin-2
- Administering cyclophosphamide
- Administering azathioprine
- Administering mycophenolate mofetil
- Administering rituximab
- Administering cyclosporine
- Administering tacrolimus
- Administering sirolimus
10 Days of Hospitalization Required
126 Hours Required for Outpatient Treatment
Common variable immunodeficiency with autoantibodies to b- or t-cells - Prevention
The best way to prevent common variable immunodeficiency with autoantibodies to b- or t-cells is to maintain good hygiene, practice safe sex, get vaccinated, and eat a balanced diet. early diagnosis and treatment are also important in preventing further complications.