(D58) Other hereditary haemolytic anaemias

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140 475 in individuals diagnosis other hereditary haemolytic anaemias confirmed

6 396 deaths with diagnosis other hereditary haemolytic anaemias

5% mortality rate associated with the disease other hereditary haemolytic anaemias

Etiology Pathogenesis Clinical Pattern Diagnostics Treatment Prevention

Diagnosis other hereditary haemolytic anaemias is diagnosed Men are 6.51% more likely than Women

74 807

Men receive the diagnosis other hereditary haemolytic anaemias

3 584 (4.8 %)

Died from this diagnosis.

100

65 668

Women receive the diagnosis other hereditary haemolytic anaemias

2 812 (4.3 %)

Died from this diagnosis.

Risk Group for the Disease other hereditary haemolytic anaemias - Men aged 5-9 and Women aged 0-5

In Men diagnosis is most often set at age 0-94

Less common in men the disease occurs at Age 95+Less common in women the disease occurs at Age 95+

In Women diagnosis is most often set at age 0-94

Disease Features other hereditary haemolytic anaemias

Non-contagious

High individual risk, low public risk

Other hereditary haemolytic anaemias - what does this mean

Other hereditary haemolytic anaemias are a group of disorders caused by a genetic mutation that affects the production of red blood cells. the mutation can cause the red blood cells to break down prematurely, leading to anaemia and other symptoms such as fatigue, pale skin, and shortness of breath. treatment may include medications to stimulate red blood cell production, blood transfusions, and lifestyle changes.

What happens during the disease - other hereditary haemolytic anaemias

Other hereditary haemolytic anaemias are a group of disorders characterized by a decreased lifespan of red blood cells (rbcs) due to an inherited abnormality in the structure or function of the rbc membrane. this abnormality can lead to premature destruction of the rbcs, resulting in a decreased number of circulating rbcs and a decrease in the amount of oxygen delivered to tissues throughout the body. the decreased lifespan of the rbcs can be caused by a variety of genetic defects, including defects in membrane proteins, enzymes, or other components of the rbc membrane.

Clinical Pattern

More details coming soon

How does a doctor diagnose

Complete Blood Count (CBC)
Blood Smear Examination
Reticulocyte Count
Coomb's Test
Osmotic Fragility Test
Haptoglobin Test
LDH Test
Bilirubin Test
Genetic Testing

Treatment and Medical Assistance

Main goal of the Treatment: To reduce the destruction of red blood cells and to increase the production of red blood cells.

Regular monitoring of red blood cell count and haemoglobin levels
Blood transfusions to replace the destroyed red blood cells
Medications to reduce the destruction of red blood cells
Medications to increase the production of red blood cells
Iron supplements to reduce the risk of iron overload
Regular exercise to improve the body's ability to use oxygen
Dietary changes to improve the body's ability to absorb nutrients
Counselling to help cope with the emotional impact of the disease

8 Days of Hospitalization Required

Average Time for Outpatient Care Not Established

Other hereditary haemolytic anaemias - Prevention

Prevention of other hereditary haemolytic anaemias is largely dependent on genetic testing prior to pregnancy, so that couples can make informed decisions about the potential risks associated with having a child with the condition. if a couple is found to be carriers of the same condition, they may opt for preimplantation genetic diagnosis or prenatal diagnosis to determine the risk of their child having the condition.

Main symptoms of the disease other hereditary haemolytic anaemias

Liver enlargement

(Hepatomegaly, Hepatic enlargement, Liver swelling, Hepatitis, Hepatomegalic, Hepatomegalia, Hepatosplenomegaly, Hepatomegalies, Hepatomegaly syndrome, Hepatic enlargement disorder)

Liver enlargement is a symptom of an underlying medical condition. It is characterized by an increase in the size of the liver, which can be felt in the right upper abdomen. It may develop gradually or suddenly, and can be accompanied by pain, nausea, vomiting, and jaundice. It can manifest as an en...

Age: 1 to 100Accociated with 49 diseases

Enlargement of the tear

(Expansion of the tear, Tear swelling, Augmentation of the tear, Tear enlargement, Tear dilatation, Tear distention, Tear extension)

Enlargement of the tear duct is a symptom which is characterized by an increase in the size of the tear duct. It may be accompanied by a feeling of fullness or pressure in the eyes, and can cause excessive tearing. It usually develops gradually over time, and its manifestations can vary depending on...

Age: 1 to 100Accociated with 32 diseases

Jaundice

(Icterus, Yellowing, Xanthochromia, Yellowing of the skin, Icteric, Icteroid, Yellow discoloration, Yellowing of the eyes, Xanthous, Icterus gravis, Icteric sclera)

Jaundice is a yellow discoloration of the skin, eyes, and mucous membranes caused by a buildup of bilirubin in the body. It usually develops gradually and is characterized by a yellowish tint to the skin, whites of the eyes, and mucous membranes. It can range from mild to severe, depending on the un...

Age: any ageAccociated with 60 diseases

Specified forms of the disease

(D58.0) Hereditary spherocytosis
(D58.1) Hereditary elliptocytosis
(D58.2) Other haemoglobinopathies
(D58.8) Other specified hereditary haemolytic anaemias
(D58.9) Hereditary haemolytic anaemia, unspecified

Diseases with similar symptoms