(L93.0) Discoid lupus erythematosus
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Diagnosis discoid lupus erythematosus is diagnosed Women are 46.39% more likely than Men
Men receive the diagnosis discoid lupus erythematosus
842 (1.8 %)Died from this diagnosis.
Women receive the diagnosis discoid lupus erythematosus
2 062 (1.6 %)Died from this diagnosis.
Risk Group for the Disease discoid lupus erythematosus - Men aged 55-59 and Women aged 50-54
Disease Features discoid lupus erythematosus
Discoid lupus erythematosus - what does this mean
What happens during the disease - discoid lupus erythematosus
При дискоидной красной волчанке наблюдается патогенетическое сходство с СКВ, однако патологические реакции ограничиваются кожными покровами. В основе заболевания лежит аутоиммунное воспаление. Под действием ультрафиолетовых лучей в совокупности с другими провоцирующими факторами в клетках кожи нарушаются процессы метилирования ДНК (механизма регуляции транскрипции генов). Это приводит к повышению экспрессии белков, индуцирующих апоптоз (запрограммированную клеточную гибель).
Т- и В-лимфоциты стимулируют синтез цитокинов и антител к компонентам клеточных ядер (нуклеиновым кислотам, нуклеосомам). Образующиеся иммунные комплексы оседают на эндотелии сосудов, вызывая их повреждение. Выработку аутоантител у генетически предрасположенных лиц также способны вызывать антигены некоторых вирусов (Эпштейна-Барр, цитомегаловирус, парвовирус 19), имеющие сходную молекулярную структуру с белками клеточных мембран. Дополнительным повреждающим агентом выступает индукция свободнорадикального окисления липидов. Результатом этих процессов является массивное воспаление и разрушение клеток кожи.
Clinical Pattern
How does a doctor diagnose
- Physical examination
- Laboratory tests including a complete blood count, urinalysis, and antinuclear antibody test
- Skin biopsy
- CT scan or MRI
- X-rays
- Echocardiogram
- Photopatch testing
- Pulmonary function tests
Treatment and Medical Assistance
- Administering corticosteroids
- Prescribing antimalarial drugs
- Prescribing immunosuppressants
- Administering topical corticosteroids
- Prescribing topical retinoids
- Prescribing topical calcineurin inhibitors
- Prescribing photoprotective agents
- Prescribing biologic medications
- Prescribing vitamin D supplements
- Encouraging stress management
- Recommending lifestyle changes
Discoid lupus erythematosus - Prevention
Main symptoms of the disease discoid lupus erythematosus
Muscle pain
(Muscle ache, Muscular soreness, Muscular discomfort, Muscle tenderness, Muscle strain, Muscle spasm, Muscle twinge, Muscle stiffness, Muscle cramp, Muscle fatigue)
Muscle pain is a symptom of an underlying medical condition. It can range from a dull ache to a sharp, burning sensation and can be localized to one area or throughout the body. It often develops gradually, starting with mild discomfort that progresses over time. Muscle pain can be caused by a varie...
Joint pain
(Arthritis, Rheumatism, Aches, Stiffness, Inflammation, Tenderness, Soreness, Swollen joints, Stabbing pain, Throbbing pain, Sharp pain, Dull ache)
Joint pain is a common symptom that can range from mild to severe. It is often caused by inflammation or injury to the joints, muscles, or tendons. It can be localized to one joint or affect multiple joints. It can be acute, lasting only a few days or chronic, lasting weeks or months. It may manifes...
Depression
(Despondency, Despair, Desolation, Gloom, Hopelessness, Despondence, Dismay, Melancholy, Dejection, Glumness, Unhappiness, Bleakness, Sorrow, Malaise)
Depression is a mental health disorder that is characterized by feeling persistently low, sad, hopeless, and empty. It can manifest through changes in mood, appetite, energy, sleep, and concentration. Symptoms may include persistent sadness, irritability, loss of interest in activities, difficulty s...
Hair loss
(Alopecia, Baldness, Thinning hair, Male-pattern baldness, Female-pattern baldness, Scarring alopecia, Telogen effluvium, Anagen effluvium, Traction alopecia)
Hair loss is a common symptom that can manifest in various forms. It can be temporary, such as telogen effluvium, or it can be permanent, such as androgenic alopecia. It can manifest as thinning of the hair, bald patches, or complete baldness. It can develop gradually or suddenly, depending on the u...
Tissue edema
(Fluid retention, Swelling, Puffiness, Fluid accumulation, Bloating, Hydrops, Dropsy, Congestion, Inflammation)
Tissue edema is an accumulation of fluid in the interstitial space of the body. It can occur in any part of the body, but is most commonly seen in the extremities, face, and abdomen. It is characterized by swelling, tenderness, and a feeling of tightness in the affected area. It may develop graduall...
Vascular asterisks
(Vascular star, Blood vessel star, Angiomata, Vascular spots, Telangiectasia, Spider veins, Capillary star, Arteriovenous malformation)
Vascular asterisks are small, red, star-shaped lesions that appear on the skin. They are caused by dilated capillaries, which can be seen under the skin. They typically develop on the face, arms, and legs, and can vary in size. They may appear suddenly or gradually, and may be itchy or painful. They...
Itching
(Irritation, Scratching, Tickling, Crawling, Burning, Prickling, Tingling, Stabbing, Throbbing)
Itching is a common symptom that can range from mild to severe. It typically presents as an uncomfortable sensation that compels the affected person to scratch the affected area. Itching can develop gradually or suddenly and can be localized or generalized. It can be caused by a variety of condition...
Spots on the skin
Spots on the skin can be caused by a variety of conditions, including infections, allergies, and even skin cancer. They can vary in size, shape, color, and texture, and can be raised or flat. Spots can develop gradually or suddenly, and may appear in clusters or as a single spot. Common types of spo...
Skin redness
(Rash, Erythema, Flushing, Inflammation, Blotchiness, Itching, Burning, Irritation, Discoloration, Tenderness)
Skin redness is a common symptom of many medical conditions. It can range from a mild pink flush on the cheeks to a deep red rash across the body. It is often accompanied by itching, burning, and swelling. It can develop quickly or over time, and can be triggered by a variety of factors such as alle...
Changes in the structure of the skin
Changes in the structure of the skin can manifest as discoloration, lesions, bumps, blisters, or other abnormalities. These changes can be caused by a variety of factors, including environmental irritants, allergies, infection, and autoimmune diseases. The changes may start as small, localized patch...
Ring lesions of the skin
(Circular skin lesions, Annular skin lesions, Ringed skin lesions, Rash with rings, Rash with circles, Circular rash, Annular rash)
Ring lesions of the skin are circular patches of discoloration that can range from red to purple in color. They typically begin as small, flat spots that can become raised, itchy, and scaly. They can also be accompanied by swelling and occasionally blisters. Over time, the lesions can grow in size a...