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(Q90.0) Trisomy 21, meiotic nondisjunction
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150 326 in individuals diagnosis trisomy 21, meiotic nondisjunction confirmed
60 678 deaths with diagnosis trisomy 21, meiotic nondisjunction
40% mortality rate associated with the disease trisomy 21, meiotic nondisjunction
Diagnosis trisomy 21, meiotic nondisjunction is diagnosed Women are 25.10% more likely than Men
56 299
Men receive the diagnosis trisomy 21, meiotic nondisjunction
30 084 (53.4 %)Died from this diagnosis.
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94 027
Women receive the diagnosis trisomy 21, meiotic nondisjunction
30 594 (32.5 %)Died from this diagnosis.
Risk Group for the Disease trisomy 21, meiotic nondisjunction - Men aged 0 and Women aged 35-39
In Men diagnosis is most often set at age 0-24, 30-39, 45-69
Less common in men the disease occurs at Age 25-29, 40-44, 70-95+Less common in women the disease occurs at Age 65-69, 75-95+
In Women diagnosis is most often set at age 0-64, 70-74
Disease Features trisomy 21, meiotic nondisjunction
Absence or low individual and public risk
Trisomy 21, meiotic nondisjunction - what does this mean
Trisomy 21, also known as down syndrome, occurs when a person has three copies of chromosome 21 instead of the usual two. this can happen when the chromosomes fail to separate properly during meiosis, a form of cell division that produces gametes, resulting in a nondisjunction.
What happens during the disease - trisomy 21, meiotic nondisjunction
Trisomy 21, also known as down syndrome, is a genetic disorder caused by meiotic nondisjunction, which results in the presence of an extra copy of chromosome 21. during meiosis, homologous chromosomes fail to separate and form an egg or sperm cell with three copies of chromosome 21 instead of the normal two. when this abnormal egg or sperm cell is fertilized, it results in an embryo with three copies of chromosome 21 and the associated down syndrome phenotype.
Clinical Pattern
More details coming soon
How does a doctor diagnose
- Physical examination
- Chromosome analysis
- Fluorescence in situ hybridization (FISH) test
- Amniocentesis
- Ultrasound
- Blood tests
Treatment and Medical Assistance
Main goal of the treatment: To improve the quality of life of individuals with Trisomy 21, meiotic nondisjunction.
- Regular monitoring of physical and mental health
- Early intervention therapies
- Speech and language therapy
- Occupational therapy
- Physical therapy
- Developmental therapies
- Nutritional guidance
- Parental support
- Educational support
- Behavioral management
- Social skills training
- Recreational activities
24 Days of Hospitalization Required
25 Hours Required for Outpatient Treatment
Trisomy 21, meiotic nondisjunction - Prevention
The primary prevention of trisomy 21, meiotic nondisjunction is through lifestyle changes and risk factor management. this includes maximizing maternal health prior to conception, avoiding alcohol and smoking, maintaining a healthy weight, and taking folic acid supplements. additionally, prenatal testing can be used to identify pregnancies at risk for trisomy 21.