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(Q92.0) Whole chromosome trisomy, meiotic nondisjunction
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6 330 in individuals diagnosis whole chromosome trisomy, meiotic nondisjunction confirmed
3 107 deaths with diagnosis whole chromosome trisomy, meiotic nondisjunction
49% mortality rate associated with the disease whole chromosome trisomy, meiotic nondisjunction
Diagnosis whole chromosome trisomy, meiotic nondisjunction is diagnosed Women are 46.76% more likely than Men
1 685
Men receive the diagnosis whole chromosome trisomy, meiotic nondisjunction
1 969 (116.9 %)Died from this diagnosis.
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4 645
Women receive the diagnosis whole chromosome trisomy, meiotic nondisjunction
1 138 (24.5 %)Died from this diagnosis.
Risk Group for the Disease whole chromosome trisomy, meiotic nondisjunction - Men and Women aged 0
In Men diagnosis is most often set at age 0-9
Less common in men the disease occurs at Age 10-95+Less common in women the disease occurs at Age 5-9, 20-24, 40-95+
In Women diagnosis is most often set at age 0-5, 10-19, 25-39
Disease Features whole chromosome trisomy, meiotic nondisjunction
Absence or low individual and public risk
Whole chromosome trisomy, meiotic nondisjunction - what does this mean
Whole chromosome trisomy, meiotic nondisjunction occurs when an individual has three copies of a chromosome instead of the normal two copies. this is caused by a failure of the chromosomes to separate correctly during meiosis, resulting in an egg or sperm cell with an extra chromosome.
What happens during the disease - whole chromosome trisomy, meiotic nondisjunction
Whole chromosome trisomy is caused by a meiotic nondisjunction event, which occurs when homologous chromosomes fail to separate during meiosis i or ii. this results in an abnormal number of chromosomes in the resulting gamete, which can cause a trisomy if it is fertilized by a normal gamete. in the case of whole chromosome trisomy, the gamete contains three copies of the same chromosome, leading to an extra chromosome in the resulting zygote.
Clinical Pattern
More details coming soon
How does a doctor diagnose
- Complete physical examination
- Blood tests
- Chromosome analysis
- Ultrasound imaging
- Amniocentesis
- Chorionic villus sampling (CVS)
Treatment and Medical Assistance
Main Goal: To treat the disease of Whole chromosome trisomy, meiotic nondisjunction.
- Genetic counseling
- Chromosome analysis
- Fetal ultrasound
- Amniocentesis
- Chorionic villus sampling (CVS)
- Blood tests
- Genetic testing
- Surgery
- Medication
- Physical therapy
- Occupational therapy
- Speech therapy
- Psychotherapy
13 Days of Hospitalization Required
Average Time for Outpatient Care Not Established
Whole chromosome trisomy, meiotic nondisjunction - Prevention
Whole chromosome trisomy, meiotic nondisjunction is a genetic disorder and is not preventable. however, prenatal testing can be done to identify the risk of this disorder and allow parents to make informed decisions about their pregnancy. genetic counseling can also be beneficial for couples who are planning to conceive.