Constant intractable pain is a type of pain that cannot be relieved by medications or other treatments, and continues for a long period of time. It may start as a mild ache, but can quickly become severe and debilitating. It may be localized to a specific area or generalized throughout the body. It can be accompanied by other symptoms such as fatigue, nausea, and depression. It can be caused by a variety of medical conditions, from chronic illnesses to nerve damage. Treatment options may include medications, physical and occupational therapy, lifestyle changes, and alternative therapies.