(D46) Myelodysplastic syndromes

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2 030 090 in individuals diagnosis myelodysplastic syndromes confirmed
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215 512 deaths with diagnosis myelodysplastic syndromes
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11% mortality rate associated with the disease myelodysplastic syndromes

Diagnosis myelodysplastic syndromes is diagnosed Men are 4.72% more likely than Women

1 062 928

Men receive the diagnosis myelodysplastic syndromes

122 283 (11.5 %)

Died from this diagnosis.

100
95
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75
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55
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967 162

Women receive the diagnosis myelodysplastic syndromes

93 229 (9.6 %)

Died from this diagnosis.

Risk Group for the Disease myelodysplastic syndromes - Men and Women aged 75-79

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In Men diagnosis is most often set at age 0-95+
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in in men, the disease manifests at any agein in women, the disease manifests at any age
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In Women diagnosis is most often set at age 0-95+

Disease Features myelodysplastic syndromes

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Non-contagious
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Moderate individual risk, low public risk
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Myelodysplastic syndromes - what does this mean

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What happens during the disease - myelodysplastic syndromes

В основе патогенеза МДС лежит воздействие повреждающих факторов на полипотентную стволовую клетку, приводящее к появлению в ней генетических аномалий, а также феномена гиперметилирования ДНК.

 

Указанные нарушения приводят к нарушению продукции клеток миелоидного ростка и появлению миелобластов в костном мозге и периферической крови, вследствие чего появляются диспластические изменения в зрелых клетках и их функциональная недостаточность, приводящие к описанным клиническим проявлениям.

 

Феномен гиперклеточности костного мозга на фоне периферической цитопении объясняется ускоренным апоптозом аномально пролиферирующих клеток костного мозга.

Clinical Pattern

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How does a doctor diagnose

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Treatment and Medical Assistance

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12 Days of Hospitalization Required
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Average Time for Outpatient Care Not Established

Myelodysplastic syndromes - Prevention

Myelodysplastic syndromes can be prevented by avoiding exposure to radiation, toxic chemicals, and certain medications; maintaining a healthy lifestyle with regular exercise and a balanced diet; and avoiding smoking and excessive alcohol consumption. additionally, regular health screenings and early detection of any signs or symptoms of myelodysplasia can help to prevent the development of the condition.

Main symptoms of the disease myelodysplastic syndromes

Conjunctival pallor

(Pale conjunctiva, Bleached conjunctiva, White conjunctiva, Pallid conjunctiva, Wan conjunctiva, Anemic conjunctiva, Ashen conjunctiva, Bloodless conjunctiva, Colorless conjunctiva)

Conjunctival pallor is a symptom characterized by a pale appearance of the conjunctiva, the thin membrane covering the white of the eye. It usually appears as a whitish discoloration, which can be seen when the eye is opened wide. It may develop gradually or suddenly and can be accompanied by other ...

Age: any ageAccociated with 6 diseases

Dysgeusia

(Distorted taste, Altered taste, Foul taste, Bitter taste, Metallic taste, Unpleasant taste, Strange taste, Off taste, Bad taste, Minty taste)

Dysgeusia is a disorder characterized by a distorted sense of taste. It often presents as a metallic, sour, or bitter taste in the mouth, but can also include other strange tastes. The disorder usually develops gradually, starting with a slight change in taste and gradually worsening over time. Symp...

Age: 1 to 100Accociated with 2 diseases

Noise in ears

(Ringing in ears, Buzzing in ears, Humming in ears, Hissing in ears, Roaring in ears, Whistling in ears, Tinnitus, Ears ringing, Ears buzzing)

Noise in the ears, also known as tinnitus, is a symptom in which a person hears a sound in their ears without an external source. It can range from a low, buzzing sound to a loud, high-pitched ringing. It can occur suddenly or gradually, and can be constant or intermittent. Tinnitus can be caused by...

Age: 1 to 100Accociated with 40 diseases

Weakness

Weakness is a lack of strength and energy that can range from mild to severe. It can be a symptom of a wide range of conditions, including physical and mental exhaustion, chronic illnesses, and certain medications. It can also be caused by a lack of nutrients, dehydration, or an underlying medical c...

Age: any ageAccociated with 291 diseases

Chills

(Shivering, Goosebumps, Feverish, Chilliness, Shuddering, Freezing, Frosty, Icy, Coldness, Numbness)

Chills are a sudden feeling of coldness accompanied by shivering and a rise in body temperature. They can be caused by exposure to cold temperatures, infections, or emotional stress. Chills typically start with a feeling of coldness and goosebumps, followed by shivering, and then a rise in body temp...

Age: 1 to 100Accociated with 73 diseases

Fever with chills

(Fever with shivering, Fever with trembling, Fever with shaking, Fever with rigors, Fever with quivering, Fever with shuddering, Fever with quaking, Fever with shudder, Fever with trembling rigors, Fever with shuddering fits)

Fever with chills is a common symptom of infection, and is characterized by a sudden onset of high body temperature and shivering. It may be accompanied by other symptoms such as sweating, headache, fatigue, body aches, and general weakness. As the body temperature rises, the patient may experience ...

Age: 1 to 100Accociated with 105 diseases

Abnormal weight loss

(Unintended weight loss, Unexplained weight loss, Rapid weight loss, Excessive weight loss, Drastic weight loss, Sudden weight loss, Substantial weight loss, Significant weight loss, Unwanted weight loss, Unexpected weight loss)

Abnormal weight loss is a symptom of an underlying medical condition. It is characterized by a significant decrease in body weight that is not related to changes in diet or exercise habits. It may be accompanied by fatigue, decreased appetite, nausea, and other symptoms. It can develop gradually or ...

Age: any ageAccociated with 97 diseases

Dizziness

(Vertigo, Lightheadedness, Giddiness, Faintness, Unsteadiness, Dazed, Spinning, Disorientation, Unbalanced, Foggy, Loss of balance, Uncoordinated, Confusion)

Dizziness is a sensation of feeling off-balance and lightheaded. It can range from mild to severe and can be accompanied by a feeling of spinning or swaying. It can develop suddenly or gradually, and can be triggered by physical activity, changes in position, or lack of food or fluids. Symptoms can ...

Age: 1 to 100Accociated with 133 diseases

Nose bleed

(Epistaxis, Nasal hemorrhage, Rhinorrhagia, Nasal haemorrhage, Nosebleed)

A nose bleed, also known as epistaxis, is a common symptom that occurs when the small blood vessels in the nose burst and bleed. It can occur suddenly, or develop gradually over time. Symptoms may include a sudden onset of bright red blood flowing from the nose, or a slow trickle of blood. Nose blee...

Age: 1 to 100Accociated with 26 diseases

Sweating

(Perspiring, Dampness, Moisture, Drenching, Dewy, Sweaty, Damp, Humid, Wetness, Clammy)

Sweating is a common symptom that can manifest itself in different ways. It can range from mild moisture on the skin to heavy perspiration. It can be localized to one area of the body or be generalized over the entire body. It usually develops in response to heat, exercise, anxiety, or emotional str...

Age: any ageAccociated with 98 diseases

Elevated temperature 37-38 °

(High temperature, Fever, Feverishness, Pyrexia, Hyperthermia, Heat, Warmth, Hyperpyrexia, Hyperthermy, Thermalgia)

Elevated temperature is a symptom of illness where the body temperature is higher than normal. It typically appears as a fever, with the temperature ranging from 37-38°C. It is often accompanied by other symptoms such as chills, body aches, and fatigue. Elevated temperature can develop over a few da...

Age: any ageAccociated with 165 diseases

Hemorrhage under the skin

Hemorrhage under the skin is a symptom characterized by the presence of blood or fluid under the skin. It may appear as a bruise, lump, or discoloration. It usually develops after a trauma or injury to the skin, but can also occur due to a medical condition. The type of hemorrhage can vary, ranging ...

Age: any ageAccociated with 25 diseases

Headache

(Cephalalgia, Hedache, Pounding head, Throbbing head, Ache, Pounding pain, Throbbing pain, Head pain, Migraine, Tension headache)

Headache is a common symptom that can range from mild to severe. It typically develops gradually and can be localized or generalized. Common types of headache include tension-type, migraine, cluster, and sinus headaches, each with their own unique characteristics and manifestations. Tension-type hea...

Age: 1 to 100Accociated with 244 diseases

Irritability and anger

(Agitation, Annoyance, Frustration, Hostility, Impatience, Impetuosity, Indignation, Irascibility, Irritation, Resentment, Testiness, Upset)

Irritability and anger are common symptoms of many psychological and physical health issues. It is characterized by frequent outbursts of anger and frustration, often in response to minor issues. It can be accompanied by feelings of restlessness, agitation, and difficulty controlling emotions. It of...

Age: 5 to 100Accociated with 53 diseases

Fatigue

(Tiredness, Exhaustion, Lethargy, Lassitude, Weariness, Burn-out, Weakness, Malaise, Lack of energy, Lack of strength, Listlessness)

Fatigue is a common symptom that can range from mild to severe. It is usually characterized by a feeling of tiredness and exhaustion that can range from mild to severe. It can develop gradually over time or suddenly, and can be caused by a variety of factors, including physical or mental stress, sle...

Age: 1 to 100Accociated with 157 diseases

Pale skin

Pale skin is a symptom of anemia or other blood-related issues. It is characterized by a lack of color in the skin, appearing wan and ashen. It may also be accompanied by fatigue, dizziness, and shortness of breath. Pale skin develops gradually due to a decrease in red blood cells or hemoglobin, whi...

Age: 1 to 100Accociated with 96 diseases

Tachycardia

(Rapid heartbeat, Fast heartbeat, Accelerated heart rate, High heart rate, Increased heart rate, Abnormal heart rhythm, Palpitations)

Tachycardia is a rapid heart rate, usually defined as a rate greater than 100 beats per minute. It is usually caused by a disruption of the normal electrical signals that control the heart's rhythm. Symptoms may include palpitations, chest pain, shortness of breath, lightheadedness, or dizziness. It...

Age: 1 to 100Accociated with 90 diseases

Specified forms of the disease

(D46.0) Refractory anaemia without ring sideroblasts, so stated
(D46.1) Refractory anaemia with ring sideroblasts
(D46.2) Refractory anaemia with excess of blasts [RAEB]
(D46.3) Рефрактерная анемия с избытком бластов с трансформацией
(D46.4) Refractory anaemia, unspecified
(D46.7) Other myelodysplastic syndromes
(D46.9) Myelodysplastic syndrome, unspecified