(M83) Adult osteomalacia
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Diagnosis adult osteomalacia is diagnosed Women are 20.49% more likely than Men
Men receive the diagnosis adult osteomalacia
0 (less than 0.1%)Died from this diagnosis.
Women receive the diagnosis adult osteomalacia
372 (4.2 %)Died from this diagnosis.
Risk Group for the Disease adult osteomalacia - Men aged 40-44 and Women aged 55-59
Disease Features adult osteomalacia
Adult osteomalacia - what does this mean
What happens during the disease - adult osteomalacia
В костях человека параллельно происходят два процесса: разрушение старой костной ткани и образование новой в сочетании с ее минерализацией. В норме эти процессы сбалансированы, поэтому кости сохраняют свою прочность. При остеомаляции вместо полноценной костной ткани образуется неминерализованный или слабо минерализованный (содержащий мало фосфатов и кальция) остеоид, представляющий собой скопление коллагеновых волокон (основу кости, белковый матрикс), которые придают костям упругость. Из-за нарушения процессов образования новой костной ткани страдает и процесс разрушения старой кости, вследствие чего строение костей еще больше нарушается, а их прочность – снижается.
Минерализация кости зависит от содержания в крови фосфатов и кальция. В зависимости от недостатка того или иного элемента различают две формы остеомаляции: кальципеническую и фосфоропеническую. Недостаток кальция может наблюдаться при нарушении всасывания кальция в кишечнике, дисбалансе между процессом отложения кальция в костях и его выведением из разрушающейся костной ткани, недостатке витамина Д и чрезмерной экскреции кальция почками. Причиной кальципенической формы остеомаляции являются врожденные и приобретенные нарушения синтеза витамина Д вследствие генетических нарушений, цирроза печени, заболеваний желудочно-кишечного тракта, недостаточной инсоляции, продолжительного приема противосудорожных препаратов и вегетарианской диеты.
Количество фосфатов в крови определяется их всасыванием в кишечнике и скоростью выведения в почках. Фосфоропеническая форма остеомаляции возникает вследствие гиперфункции паращитовидных желез (гиперпаратиреоза), недостатка фосфатов в пище и усиленной секреции фосфатов почками при некоторых опухолях, наследственных нарушениях обмена веществ, болезнях почек и т. д. В период беременности и лактации риск развития остеомаляции увеличивается, поскольку потребность организма в витамине Д возрастает, а нагрузка на почки повышается, что может приводить к манифестации различных заболеваний и проявлению ранее латентно протекавших аномалий развития.
Clinical Pattern
How does a doctor diagnose
Treatment and Medical Assistance
Adult osteomalacia - Prevention
Main symptoms of the disease adult osteomalacia
Joint pain
(Arthritis, Rheumatism, Aches, Stiffness, Inflammation, Tenderness, Soreness, Swollen joints, Stabbing pain, Throbbing pain, Sharp pain, Dull ache)
Joint pain is a common symptom that can range from mild to severe. It is often caused by inflammation or injury to the joints, muscles, or tendons. It can be localized to one joint or affect multiple joints. It can be acute, lasting only a few days or chronic, lasting weeks or months. It may manifes...
Pain when walking
(Ache, Achey, Aching, Agony, Anguish, Distress, Hurt, Misery, Pang, Soreness, Sting, Suffering, Throb, Torment, Torture)
Pain when walking is a common symptom that can present in a variety of ways. It can start as a dull ache that gradually worsens with activity or can be sudden and sharp. It can be localized to one area, or may radiate to other areas of the body. It can be accompanied by swelling, redness, or warmth ...
Muscle weakness
(Aching muscles, Lack of strength, Muscular fatigue, Decreased muscle power, Reduced muscle tone, Muscle exhaustion, Muscle debility, Lack of muscle control, Lack of muscular coordination, Loss of muscle strength)
Muscle weakness is a decrease in the strength of the muscles that can lead to difficulty in performing everyday tasks. It can manifest in a variety of ways, including fatigue, difficulty walking, and reduced range of motion. It can develop gradually or suddenly, and can be caused by a variety of med...
Pain in the bones
(Aches, Agony, Distress, Misery, Soreness, Suffering, Torture, Torment, Agonizing, Tenderness, Throbbing, Sharpness, Stabbing, Pricking, Twinge, Throb, Pang)
Bone pain is a dull, deep, aching sensation that is felt in the bones or joints. It can range from mild to severe, and can be a constant or an intermittent ache. It can develop suddenly or gradually, and can be localized to one area or widespread throughout the body. It can manifest as a sharp, stab...
Pain in the legs
(Agony in the legs, Soreness in the legs, Aching in the legs, Throbbing in the legs, Discomfort in the legs, Tenderness in the legs, Stiffness in the legs, Pricking in the legs, Burning in the legs)
Pain in the legs can manifest in a variety of ways, ranging from a dull ache to a sharp, stabbing sensation. It can affect any part of the leg, from the hip to the ankle. It can develop gradually over time, or suddenly after an injury or illness. It can be a sign of an underlying medical condition, ...
Foot pain
(Ankle pain, Arch pain, Heel pain, Leg pain, Sole pain, Toe pain, Plantar pain, Ball of foot pain, Metatarsalgia)
Foot pain is a common symptom that can range from mild to severe. It can be caused by a variety of conditions such as arthritis, overuse, trauma, or deformity. It often begins as a dull ache or soreness and can worsen with activity or pressure. It can be localized to one area of the foot or spread t...
Pain in the ribs
(Sore ribs, Aching ribs, Agonizing ribs, Tender ribs, Throbbing ribs, Sharp ribs, Stabbing ribs, Piercing ribs, Cramping ribs, Burning ribs)
Pain in the ribs can be sharp, stabbing, or aching and can be located in the front or back of the chest. It usually develops gradually and can be worse with movement or deep breaths. There are several types of rib pain, including costochondritis, muscle strain, or fractures. Costochondritis is an in...
Scoliosis
(Spinal curvature, Curvature of the spine, Lateral curvature of the spine, Abnormal curvature of the spine, Side-to-side curvature of the spine, Lateral spinal deviation, Asymmetrical spinal curvature, Abnormal lateral curvature of the spine)
Scoliosis is a condition where the spine curves sideways in an "S" or "C" shape instead of its normal straight line. It can develop in childhood or adolescence and is characterized by uneven shoulders, a tilted pelvis, and a raised or lowered hip. It can also cause pain, fatigue, and respiratory pro...
Gait disorders
(Gait disturbances, Gait abnormalities, Walking problems, Gait instability, Gait imbalance, Gait impairment, Gait dysfunction, Gait abnormality, Gait irregularity, Gait difficulty)
Gait disorders are impairments in walking that can range from mild to severe. Symptoms can include an unsteady walk, shuffling, tripping, or dragging one foot. Gait disorders may be caused by a variety of conditions, such as stroke, Parkinson’s disease, dementia, traumatic brain injury, multiple scl...