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(D64.2) Secondary sideroblastic anaemia due to drugs and toxins
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4 889 367 in individuals diagnosis secondary sideroblastic anaemia due to drugs and toxins confirmed
90 104 deaths with diagnosis secondary sideroblastic anaemia due to drugs and toxins
2% mortality rate associated with the disease secondary sideroblastic anaemia due to drugs and toxins
Diagnosis secondary sideroblastic anaemia due to drugs and toxins is diagnosed Women are 6.31% more likely than Men
2 290 469
Men receive the diagnosis secondary sideroblastic anaemia due to drugs and toxins
40 996 (1.8 %)Died from this diagnosis.
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2 598 898
Women receive the diagnosis secondary sideroblastic anaemia due to drugs and toxins
49 108 (1.9 %)Died from this diagnosis.
Risk Group for the Disease secondary sideroblastic anaemia due to drugs and toxins - Men aged 75-79 and Women aged 80-84
In Men diagnosis is most often set at age 0-95+
in in men, the disease manifests at any agein in women, the disease manifests at any age
In Women diagnosis is most often set at age 0-95+
Disease Features secondary sideroblastic anaemia due to drugs and toxins
Absence or low individual and public risk
Secondary sideroblastic anaemia due to drugs and toxins - what does this mean
Secondary sideroblastic anaemia due to drugs and toxins is caused by the toxic effects of certain drugs or toxins on the bone marrow, resulting in the inhibition of haemoglobin production and an abnormal accumulation of iron in the mitochondria of red blood cells. this leads to a decrease in red blood cell production and a decrease in the oxygen-carrying capacity of the blood.
What happens during the disease - secondary sideroblastic anaemia due to drugs and toxins
Secondary sideroblastic anaemia due to drugs and toxins is caused by the interference of drugs and toxins with the normal heme biosynthesis pathway. these substances can inhibit the activity of enzymes involved in the pathway, leading to an accumulation of non-functional precursors in the mitochondria. this results in the formation of ringed sideroblasts, which are ineffective at producing functional haemoglobin, leading to a decrease in the production of red blood cells and the development of anaemia.
Clinical Pattern
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How does a doctor diagnose
- Complete blood count (CBC)
- Peripheral blood smear
- Serum iron, ferritin, and transferrin saturation
- Bone marrow biopsy and aspiration
- Serum vitamin B12 and folate levels
- Liver function tests
- Urinalysis
- Toxicology screen
- Drug history
Treatment and Medical Assistance
Main Goal: To treat the Secondary sideroblastic anaemia due to drugs and toxins.
- Discontinue the use of drugs and toxins that are causing the anaemia.
- Administer iron supplements to replenish iron stores.
- Administer Vitamin B6 supplements to improve the absorption of iron.
- Administer folic acid supplements to improve red blood cell production.
- Perform blood transfusions to increase the number of red blood cells.
- Perform bone marrow transplant to replace damaged bone marrow.
- Administer steroids to reduce inflammation.
- Administer immunosuppressants to reduce the body's immune response.
13 Days of Hospitalization Required
Average Time for Outpatient Care Not Established
Secondary sideroblastic anaemia due to drugs and toxins - Prevention
The best way to prevent secondary sideroblastic anaemia due to drugs and toxins is to avoid exposure to the substances that cause the condition. this includes avoiding or limiting the use of certain medications, such as alcohol, chemotherapy drugs, and certain antibiotics. it is also important to avoid exposure to environmental toxins, such as lead, arsenic, mercury, and other heavy metals.