(D74) Methaemoglobinaemia

More details coming soon

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4 596 in individuals diagnosis methaemoglobinaemia confirmed
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3 577 deaths with diagnosis methaemoglobinaemia
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78% mortality rate associated with the disease methaemoglobinaemia

Diagnosis methaemoglobinaemia is diagnosed Women are 24.98% more likely than Men

1 724

Men receive the diagnosis methaemoglobinaemia

0 (less than 0.1%)

Died from this diagnosis.

100
95
90
85
80
75
70
65
60
55
50
45
40
35
30
25
20
15
10
5
0
2 872

Women receive the diagnosis methaemoglobinaemia

3 577 (124.5 %)

Died from this diagnosis.

Risk Group for the Disease methaemoglobinaemia - Men and Women aged 0

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In Men diagnosis is most often set at age 0-5, 20-24, 35-39, 50-59, 65-69
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Less common in men the disease occurs at Age 5-19, 25-34, 40-49, 60-64, 70-95+Less common in women the disease occurs at Age 0-5, 10-14, 25-54, 70-74, 80-95+
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In Women diagnosis is most often set at age 0-1, 5-9, 15-24, 55-69, 75-79

Disease Features methaemoglobinaemia

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Non-contagious
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Moderate individual risk, low public risk
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Methaemoglobinaemia - what does this mean

Methaemoglobinaemia is a rare disorder caused by an inherited or acquired deficiency in the enzyme cytochrome b5 reductase, which leads to the accumulation of methaemoglobin in the blood. this can result in a decrease in the oxygen-carrying capacity of the blood, causing fatigue, dizziness, headache, and shortness of breath.

What happens during the disease - methaemoglobinaemia

Methaemoglobinaemia is a rare condition caused by a deficiency of the enzyme cytochrome b5 reductase, which is responsible for the reduction of oxidised methaemoglobin to normal haemoglobin. this results in an accumulation of methaemoglobin in the blood, leading to a decrease in oxygen-carrying capacity and a range of symptoms including cyanosis, fatigue, dizziness, and headache.

Clinical Pattern

More details coming soon

How does a doctor diagnose

  • Complete Blood Count (CBC)
  • Blood Gas Analysis
  • Blood Smear Examination
  • Serum Ferritin Level Test
  • Serum Bilirubin Level Test
  • Methylene Blue Test
  • Urine Methemoglobin Test
  • Hemoglobin Electrophoresis

Treatment and Medical Assistance

Main Goal: To reduce the amount of methaemoglobin in the blood
  • Prescribing medications to reduce the amount of methaemoglobin in the blood
  • Administering oxygen therapy to increase the oxygen-carrying capacity of the blood
  • Providing supportive care to reduce the symptoms of the disease
  • Regular monitoring of the patient's condition to assess the effectiveness of the treatment
  • Providing dietary and lifestyle advice to reduce the risk of recurrence of methaemoglobinaemia
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10 Days of Hospitalization Required
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Average Time for Outpatient Care Not Established

Methaemoglobinaemia - Prevention

Methaemoglobinaemia can be prevented by avoiding exposure to certain industrial chemicals, such as nitrites, nitrates, and aniline dyes, which are known to cause the condition. furthermore, avoiding activities that increase the risk of inhaling or ingesting these chemicals, such as working in a factory or industrial area, can also help reduce the risk of developing methaemoglobinaemia.

Main symptoms of the disease methaemoglobinaemia

Violation of mental processes

Mental processes violations manifest as a disruption in thinking, memory, problem-solving, and communication. Symptoms can include confusion, disorientation, difficulty concentrating, and difficulty with decision-making. In more severe cases, hallucinations and delusions may also occur. Symptoms can...

Age: 1 to 100Accociated with 11 diseases

Conjunctival pallor

(Pale conjunctiva, Bleached conjunctiva, White conjunctiva, Pallid conjunctiva, Wan conjunctiva, Anemic conjunctiva, Ashen conjunctiva, Bloodless conjunctiva, Colorless conjunctiva)

Conjunctival pallor is a symptom characterized by a pale appearance of the conjunctiva, the thin membrane covering the white of the eye. It usually appears as a whitish discoloration, which can be seen when the eye is opened wide. It may develop gradually or suddenly and can be accompanied by other ...

Age: any ageAccociated with 6 diseases

Chest pain

(Thoracic pain, Thorax pain, Rib cage pain, Rib pain, Breastbone pain, Sternum pain, Costal pain, Intercostal pain, Pectoral pain, Precordial pain)

Chest pain is a common symptom that can range from mild to severe. It may be described as pressure, squeezing, burning, or tightness in the chest. It can develop quickly or gradually, and can be accompanied by other symptoms such as nausea, sweating, or shortness of breath. Types of chest pain inclu...

Age: any ageAccociated with 55 diseases

Dizziness

(Vertigo, Lightheadedness, Giddiness, Faintness, Unsteadiness, Dazed, Spinning, Disorientation, Unbalanced, Foggy, Loss of balance, Uncoordinated, Confusion)

Dizziness is a sensation of feeling off-balance and lightheaded. It can range from mild to severe and can be accompanied by a feeling of spinning or swaying. It can develop suddenly or gradually, and can be triggered by physical activity, changes in position, or lack of food or fluids. Symptoms can ...

Age: 1 to 100Accociated with 133 diseases

Clouding of consciousness

Clouding of consciousness is a symptom of decreased alertness, confusion, and disorientation. It is often caused by a medical condition, such as a stroke, head trauma, or drug overdose. It can also be caused by a lack of sleep, dehydration, or intoxication. The symptom manifests itself in a decrease...

Age: 1 to 100Accociated with 17 diseases

Cardiopalmus

(Heart palpitations, Heart fluttering, Heart racing, Skipped beats, Pounding heart, Heart throbbing, Heart thumping, Heart pounding, Heart skipping, Heart quivering)

Cardiopalmus is an irregular heartbeat, characterized by a rapid and/or forceful heartbeat. It can vary in intensity and duration and often develops gradually over time. Symptoms can range from a fluttering sensation in the chest to a racing heart rate. It can also be accompanied by chest pain, dizz...

Age: 1 to 100Accociated with 45 diseases

Dementia

Dementia is a symptom of a wide range of conditions that affect the brain. It is characterised by a decline in cognitive function, including memory, language, problem-solving, and judgement. It can also affect behaviour, emotions, and the ability to perform everyday activities. Symptoms typically de...

Age: 1 to 100Accociated with 19 diseases

Cyanosis

(Bluish skin, Blue skin, Blue discoloration, Blue tint, Blue hue, Bluish tinge, Cyanotic discoloration, Cyanotic hue, Cyanotic tint, Cyanotic skin, Blue-tinged skin)

Cyanosis is a medical symptom characterized by a bluish discoloration of the skin and mucous membranes, due to a lack of oxygen in the blood. It is most commonly seen around the lips, fingers, and toes, and can range in severity from mild to life-threatening. Early signs may include a faint bluish t...

Age: any ageAccociated with 79 diseases

Pale skin

Pale skin is a symptom of anemia or other blood-related issues. It is characterized by a lack of color in the skin, appearing wan and ashen. It may also be accompanied by fatigue, dizziness, and shortness of breath. Pale skin develops gradually due to a decrease in red blood cells or hemoglobin, whi...

Age: 1 to 100Accociated with 96 diseases

Headache

(Cephalalgia, Hedache, Pounding head, Throbbing head, Ache, Pounding pain, Throbbing pain, Head pain, Migraine, Tension headache)

Headache is a common symptom that can range from mild to severe. It typically develops gradually and can be localized or generalized. Common types of headache include tension-type, migraine, cluster, and sinus headaches, each with their own unique characteristics and manifestations. Tension-type hea...

Age: 1 to 100Accociated with 244 diseases

Spasm

(Twitching, Contraction, Cramp, Jerking, Convulsion, Muscle spasm, Tic, Clonus, Myoclonus, Spasmodic)

A spasm is a sudden, involuntary muscle contraction that can cause pain and discomfort. It can occur in any muscle group and can be caused by a variety of different conditions. Symptoms of a spasm can include tightness, pain, and difficulty moving the affected muscle. Spasms can develop suddenly or ...

Age: 1 to 100Accociated with 56 diseases

Fainting

(Syncope, Swoon, Passing out, Losing consciousness, Blackout, Dizziness, Unconsciousness)

Fainting is a sudden, brief loss of consciousness and muscle tone, usually caused by a drop in blood pressure. It is often accompanied by a feeling of dizziness, lightheadedness, and confusion. Fainting usually occurs in response to a sudden emotional or physical stressor, such as standing for a lon...

Age: 1 to 100Accociated with 56 diseases

Weakness

Weakness is a lack of strength and energy that can range from mild to severe. It can be a symptom of a wide range of conditions, including physical and mental exhaustion, chronic illnesses, and certain medications. It can also be caused by a lack of nutrients, dehydration, or an underlying medical c...

Age: any ageAccociated with 291 diseases

Specified forms of the disease

(D74.0) Congenital methaemoglobinaemia
(D74.8) Other methaemoglobinaemias
(D74.9) Methaemoglobinaemia, unspecified