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(D84.1) Defects in the complement system
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263 079 in individuals diagnosis defects in the complement system confirmed
14 071 deaths with diagnosis defects in the complement system
5% mortality rate associated with the disease defects in the complement system
Diagnosis defects in the complement system is diagnosed Men are 4.10% more likely than Women
136 927
Men receive the diagnosis defects in the complement system
6 596 (4.8 %)Died from this diagnosis.
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126 152
Women receive the diagnosis defects in the complement system
7 475 (5.9 %)Died from this diagnosis.
Risk Group for the Disease defects in the complement system - Men and Women aged 0-5
In Men diagnosis is most often set at age 0-89
Less common in men the disease occurs at Age 90-95+Less common in women the disease occurs at Age 90-95+
In Women diagnosis is most often set at age 0-89
Disease Features defects in the complement system
Absence or low individual and public risk
Defects in the complement system - what does this mean
Defects in the complement system occur when mutations in the genes that encode the proteins involved in the complement system lead to an impaired ability of the body to respond to foreign substances, resulting in an increased risk of infection, autoimmune disorders, and other inflammatory conditions.
What happens during the disease - defects in the complement system
Defects in the complement system occur when the proteins responsible for mediating the immune response are unable to function properly. this can lead to an increased risk of infection, autoimmune disorders, and other inflammatory conditions. in some cases, these defects can also lead to an increased risk of developing certain types of cancer.
Clinical Pattern
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How does a doctor diagnose
- Complete blood count (CBC)
- C3 and C4 levels
- CH50 assay
- Flow cytometry
- ELISA testing
- Western blot analysis
- Complement receptor 1 (CR1) assay
- Antinuclear antibody (ANA) testing
- Immunofluorescence assay (IFA)
Treatment and Medical Assistance
Main goal of the treatment: Treating Defects in the Complement System
- Administering intravenous immunoglobulin (IVIG) to replace missing complement proteins.
- Providing antibiotics to treat any infections that result from the complement deficiency.
- Administering hematopoietic stem cell transplantation (HSCT) to replace the defective stem cells.
- Performing plasma exchange therapy to remove abnormal complement proteins.
- Prescribing medications to suppress the immune system.
- Providing genetic counseling to help affected individuals and their families understand the condition and its inheritance.
8 Days of Hospitalization Required
42 Hours Required for Outpatient Treatment
Defects in the complement system - Prevention
The best way to prevent defects in the complement system is to ensure that your diet is rich in essential nutrients such as vitamins, minerals, and antioxidants. eating a balanced diet, getting regular exercise, and avoiding smoking and excessive alcohol consumption can help keep the complement system functioning properly. additionally, getting regular medical check-ups and following your doctor's advice can help identify any deficiencies in the complement system before they become a problem.