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(D60) Acquired pure red cell aplasia [erythroblastopenia]
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50 491 in individuals diagnosis acquired pure red cell aplasia [erythroblastopenia] confirmed
2 177 deaths with diagnosis acquired pure red cell aplasia [erythroblastopenia]
4% mortality rate associated with the disease acquired pure red cell aplasia [erythroblastopenia]
Diagnosis acquired pure red cell aplasia [erythroblastopenia] is diagnosed Men are 0.61% more likely than Women
25 399
Men receive the diagnosis acquired pure red cell aplasia [erythroblastopenia]
1 068 (4.2 %)Died from this diagnosis.
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25 092
Women receive the diagnosis acquired pure red cell aplasia [erythroblastopenia]
1 109 (4.4 %)Died from this diagnosis.
Risk Group for the Disease acquired pure red cell aplasia [erythroblastopenia] - Men aged 80-84 and Women aged 50-54
In Men diagnosis is most often set at age 0-19, 25-34, 55-89
Less common in men the disease occurs at Age 20-24, 35-54, 90-95+in in women, the disease manifests at any age
In Women diagnosis is most often set at age 0-95+
Disease Features acquired pure red cell aplasia [erythroblastopenia]
Absence or low individual and public risk
Acquired pure red cell aplasia [erythroblastopenia] - what does this mean
Acquired pure red cell aplasia (erythroblastopenia) is a rare condition in which the body's bone marrow does not produce enough red blood cells. this can be caused by autoimmune disorders, certain medications, or certain viral infections.
What happens during the disease - acquired pure red cell aplasia [erythroblastopenia]
Acquired pure red cell aplasia (erythroblastopenia) is a rare disorder caused by an autoimmune response, in which the body's own immune system attacks and destroys the bone marrow's stem cells, which are responsible for producing red blood cells. this leads to a decrease in red blood cell production, resulting in anemia. in some cases, the cause of the autoimmune response is unknown, while in others it may be due to an underlying infection or medication.
Clinical Pattern
More details coming soon
How does a doctor diagnose
- Complete blood count (CBC) with peripheral smear
- Bone marrow aspiration and biopsy
- Serum iron studies
- Serum ferritin
- Serum vitamin B12 and folate levels
- Serum immunoglobulin levels
- Anti-nuclear antibody (ANA) and anti-neutrophil cytoplasmic antibody (ANCA) levels
- Thyroid-stimulating hormone (TSH) level
- Serum erythropoietin level
- Flow cytometry for B and T cell subsets
- Molecular tests for gene mutations
Treatment and Medical Assistance
Main Goal: Treat Acquired Pure Red Cell Aplasia (Erythroblastopenia)
- Perform a physical examination to assess the patient's condition.
- Order laboratory tests to confirm the diagnosis and rule out other possible causes.
- Administer immunosuppressive medications such as prednisone or cyclosporine.
- Administer intravenous immunoglobulin (IVIG) or antithymocyte globulin (ATG) to suppress the immune system.
- Administer blood transfusions to replace the missing red blood cells.
- Administer growth factors such as erythropoietin to stimulate red blood cell production.
- Provide supportive care such as iron supplements and nutritional support.
- Monitor the patient's response to treatment and adjust medications accordingly.
15 Days of Hospitalization Required
Average Time for Outpatient Care Not Established
Acquired pure red cell aplasia [erythroblastopenia] - Prevention
The best way to prevent acquired pure red cell aplasia (erythroblastopenia) is to avoid exposure to known triggers such as certain medications, infections, and autoimmune diseases. vaccinations for certain infections can also help reduce the risk of developing the condition. additionally, it is important to maintain good general health through a balanced diet, regular exercise, and adequate rest.