(R17) Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
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Diagnosis hyperbilirubinaemia, with or without jaundice, not elsewhere classified is diagnosed Men are 15.19% more likely than Women
Men receive the diagnosis hyperbilirubinaemia, with or without jaundice, not elsewhere classified
1 469 (0.4 %)Died from this diagnosis.
Women receive the diagnosis hyperbilirubinaemia, with or without jaundice, not elsewhere classified
2 160 (0.7 %)Died from this diagnosis.
Risk Group for the Disease hyperbilirubinaemia, with or without jaundice, not elsewhere classified - Men and Women aged 0
Disease Features hyperbilirubinaemia, with or without jaundice, not elsewhere classified
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified - what does this mean
What happens during the disease - hyperbilirubinaemia, with or without jaundice, not elsewhere classified
Механизм развития желтухи зависит от причин, вызвавших расстройство.
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При печеночно-клеточных вариантах желтушного синдрома, обусловленных инфекционным, токсическим повреждением печени, склеротическими процессами, злокачественным перерождением органа, уменьшается количество активных гепатоцитов, обратимо или необратимо снижается их функциональность. В результате нарушается захват свободного билирубина из крови, его глюкуронизация и экскреция с желчью. Пусковым моментом холестатического варианта гепатоцеллюлярной желтухи становится нарушение выделения желчи, приводящее к ее стазу и вторичному цитолизу печеночных клеток.
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При наследственных формах ключевым звеном является нарушение конъюгации несвязанного пигмента, связанное с врожденной ферментной недостаточностью, или задержка в гепатоцитах связанного билирубина из-за генетического дефекта АТФ-зависимой транспортной системы.
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Независимо от особенностей пусковых моментов патогенеза в конечном результате в крови повышается содержание как свободного, так и связанного билирубина. За счет прямой билирубинемии возрастает фильтрация пигмента почками, что приводит к билирубинурии и потемнению мочи. Из-за недостаточной экскреции билирубина в желчь снижается количество стеркобилиногена и стеркобилина, вследствие чего кал становится светлым. При тяжелом повреждении печеночных тканей может нарушаться обмен уробилиногена, желчных кислот.
Clinical Pattern
How does a doctor diagnose
- Complete physical examination
- Complete blood count (CBC) and peripheral smear
- Liver function tests (LFTs) including bilirubin, alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT)
- Serum albumin and total protein levels
- Serum electrolytes, including sodium, potassium, chloride and bicarbonate
- Thyroid function tests (TFTs)
- Urine analysis
- Imaging studies such as ultrasound, computed tomography (CT) or magnetic resonance imaging (MRI)
- Liver biopsy
- Genetic testing
Treatment and Medical Assistance
- Monitor bilirubin levels.
- Administer phototherapy.
- Administer intravenous immunoglobulin (IVIG).
- Administer exchange transfusions.
- Administer oral medications.
- Administer parenteral nutrition.
- Provide supportive care.
- Monitor for complications.
- Provide education to patient and family.
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified - Prevention
Main symptoms of the disease hyperbilirubinaemia, with or without jaundice, not elsewhere classified
Pain in the left hypochondrium
(Ache in the left upper abdomen, Discomfort in the left upper abdomen, Soreness in the left upper abdomen, Aching in the left upper abdomen, Throbbing in the left upper abdomen, Tenderness in the left upper abdomen, Stinging in the left upper abdomen,...)
Pain in the left hypochondrium is a common symptom that can arise from a variety of causes. It is typically described as a sharp, stabbing pain in the upper left side of the abdomen. It can develop suddenly or gradually, and can range from mild to severe. It may be accompanied by other symptoms such...
Pain in the abdomen with pressure
(Abdominal discomfort, Stomach ache, Abdominal soreness, Abdominal tenderness, Abdominal distress, Abdominal aching, Abdominal tightness, Gut pain, Gut pressure, Bellyache, Belly discomfort, Belly pain)
Pain in the abdomen with pressure is a common symptom that can range from mild to severe. It can be described as a dull ache or a sharp, stabbing sensation. It may start suddenly or develop gradually and can be localized to one area or widespread. It can be accompanied by nausea, vomiting, bloating,...
Itching
(Irritation, Scratching, Tickling, Crawling, Burning, Prickling, Tingling, Stabbing, Throbbing)
Itching is a common symptom that can range from mild to severe. It typically presents as an uncomfortable sensation that compels the affected person to scratch the affected area. Itching can develop gradually or suddenly and can be localized or generalized. It can be caused by a variety of condition...
Hematemesis
(Vomiting blood, Gastrointestinal bleeding, Vomiting of blood, Vomiting up blood, Bloody vomit, Upper gi bleeding, Upper gastrointestinal bleeding, Vomiting of red material, Vomiting bright red blood, Vomiting dark red blood)
Hematemesis is the vomiting of blood or the presence of blood in the vomit. It can range from a small amount of bright red blood to large amounts of dark, partially digested blood. It is usually accompanied by nausea, abdominal pain, and other gastrointestinal symptoms. It can be caused by a variety...
Jaundice
(Icterus, Yellowing, Xanthochromia, Yellowing of the skin, Icteric, Icteroid, Yellow discoloration, Yellowing of the eyes, Xanthous, Icterus gravis, Icteric sclera)
Jaundice is a yellow discoloration of the skin, eyes, and mucous membranes caused by a buildup of bilirubin in the body. It usually develops gradually and is characterized by a yellowish tint to the skin, whites of the eyes, and mucous membranes. It can range from mild to severe, depending on the un...
Nausea
(Upset stomach, Queasiness, Queasy feeling, Stomach discomfort, Gastric unease, Stomach churning, Stomach upset, Stomachache, Feeling sick, Feeling queasy, Stomach queasiness, Feeling nauseous, Feeling nauseated, Nauseousness)
Nausea is an unpleasant feeling in the upper abdomen that may be accompanied by an urge to vomit. It can range from mild to severe and can be accompanied by symptoms such as sweating, dizziness, and increased salivation. Nausea can be caused by a variety of stimuli, including motion sickness, certai...
Liver enlargement
(Hepatomegaly, Hepatic enlargement, Liver swelling, Hepatitis, Hepatomegalic, Hepatomegalia, Hepatosplenomegaly, Hepatomegalies, Hepatomegaly syndrome, Hepatic enlargement disorder)
Liver enlargement is a symptom of an underlying medical condition. It is characterized by an increase in the size of the liver, which can be felt in the right upper abdomen. It may develop gradually or suddenly, and can be accompanied by pain, nausea, vomiting, and jaundice. It can manifest as an en...
Drowsiness
(Sleepiness, Fatigue, Lethargy, Sluggishness, Exhaustion, Languor, Listlessness, Torpor, Stupor, Dullness, Lassitude)
Drowsiness is a symptom characterized by an overwhelming feeling of tiredness and a strong desire to sleep. It usually develops gradually, with a feeling of heaviness in the eyelids and a lack of energy. It can be caused by various conditions, such as lack of sleep, certain medications, or certain m...
Urine color changes
Urine color changes can range from a deep yellow to a light straw color. It can also appear cloudy, dark, or reddish-brown. This symptom can be caused by a variety of factors, from diet to dehydration to certain medications. It can also be a sign of underlying medical conditions, such as infection o...
Elevated temperature 37-38 °
(High temperature, Fever, Feverishness, Pyrexia, Hyperthermia, Heat, Warmth, Hyperpyrexia, Hyperthermy, Thermalgia)
Elevated temperature is a symptom of illness where the body temperature is higher than normal. It typically appears as a fever, with the temperature ranging from 37-38°C. It is often accompanied by other symptoms such as chills, body aches, and fatigue. Elevated temperature can develop over a few da...